These details gleaned from this regenerative process in the mouse organoid provides insights into how mammalian supporting cells could be reprogrammed into hair cells.
Cochlear Organoids Reveal How Supporting Cells Differentiate Into Hair Cells
A Boost to Inner Ear Organoid Development
This paper explored the potential of the stem cell-derived inner ear organoid system for studying early mammalian placode development. The results will benefit future inner ear organoid applications, such as high-throughput drug screening and cell therapy.
Impact 2021
Hearing Health Foundation is grateful for the support of our community to advance our mission to find better treatments and cures for hearing loss, tinnitus, and related conditions in 2021. We’re proud to share this list of significant scientific achievements this past year.
Cochlear Organoids Reveal HIC1’s Role in Hair Cell Differentiation
Emerging Research Grants scientist Dunia Abdul-Aziz, M.D., of Harvard Medical School and Mass Eye and Ear coauthored a study that reveals how the gene Atoh1 in the cochlea can be repressed by the protein HIC1, inhibiting hair cell differentiation. It also demonstrates the power of combining the organoid model with the genetic toolkit to study key regulators of hair cell differentiation, which may help advance the understanding of hair cell development and regeneration.