single-cell analysis

An Essential Signaling Cascade for Hair Cell Regeneration in Birds

This work provides a new starting point to investigate the natural triggers of hair cell regeneration in birds. We also identified novel genes that drive hair cell regeneration in the chicken inner ear. These novel genes will be key for investigating their potential role in triggering a change in supporting cells in mammals, in the damaged mouse or human cochlea.

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Highlights From the Hearing Restoration Project 

Here are highlights of recent accomplishments, including demonstrating that a cocktail of three factors can promote conversion of nonsensory cells into hair cells in the mouse model.

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Data Made Visual

Over the past several years, Hearing Health Foundation (HHF)’s Hearing Restoration Project (HRP) has generated a significant amount of data. Part of the challenge for HRP consortium members, as for many life scientists, comes not only from the amount of data they need to analyze but also the need to examine multi-omic datasets.

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