The collaborative spirit of our Hearing Restoration Project consortium is especially evident as we work together to complete a publication describing our analysis of hair cell gene expression.
HHF Is 65 This Year!
More funding and more time leads to more ambitious experimental plans, additional data collected, and a stronger footing for subsequent research and research funding.
Highlights From the Hearing Restoration Project
Here are highlights of recent accomplishments, including demonstrating that a cocktail of three factors can promote conversion of nonsensory cells into hair cells in the mouse model.
Hope for Treatments Against Hearing Loss as 10 New Genes Identified
Researchers argue that the stria vascularis, a part of the cochlea in the ear, is a new target for treatments to help people with hearing loss.
Advancing Discoveries via Biologist-Friendly Access to Multi-Omic Data
Data processing that analyzes a large amount of data about individual cells and measures them through multiple “omics” (such as genomics, transcriptomics, proteomics, epigenomics, and metabolomics) have advanced our understanding of biological sciences and medicine in an unprecedented way.
Understanding Hearing Loss From Noise Damage Through Gene Expression Changes
Findings suggest several FDA-approved drugs, such as a common diabetes medication and anesthetics, could protect from noise-induced hearing loss.
New High-Tech Portal Launched to Speed Innovations to Reverse Hearing Loss
Researchers at the University of Maryland School of Medicine (UMSOM) including Hearing Restoration Project (HRP) member Ronna Hertzano, M.D., PhD., launched a new online tool that could more quickly advance medical discoveries to reverse progressive hearing loss.
Webinar Recap: The Present and Future of Inner Ear Hair Cell Regeneration
On July 12, Hearing Health Foundation (HHF) hosted “The Present and Future of Inner Ear Hair Cell Regeneration” on Zoom. This webinar was co-presented by 2009-2010 ERG scientist Ronna Hertzano, M.D., Ph.D. of the Hearing Restoration Project, and the consortium’s scientific director, Lisa Goodrich, Ph.D.
Study Charts Developmental Map of Inner Ear Sound Sensor in Mice
Scientists at the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, and their collaborators analyzed data from 30,000 cells from mouse cochlea, the snail-shaped structure of the inner ear. The results provide insights into the genetic programs that drive the formation of cells important for detecting sounds. The study also sheds light specifically on the underlying cause of hearing loss linked to Ehlers-Danlos syndrome and Loeys-Dietz syndrome.
Data Made Visual
Over the past several years, Hearing Health Foundation (HHF)’s Hearing Restoration Project (HRP) has generated a significant amount of data. Part of the challenge for HRP consortium members, as for many life scientists, comes not only from the amount of data they need to analyze but also the need to examine multi-omic datasets.