Since 2014 the Les Paul Foundation has funded six Emerging Research Grants on tinnitus, deepening our understanding of its causes as well as improving diagnosis, treatment, and prevention.
Hope for Treatments Against Hearing Loss as 10 New Genes Identified
Researchers argue that the stria vascularis, a part of the cochlea in the ear, is a new target for treatments to help people with hearing loss.
Using Algorithms to Measure Brain Response Times to Auditory Nerve Stimulation
The proposed algorithms could provide a clue on the signal response and its shifts in the brain during the development of hyperactivity, a neural mechanism of tinnitus, and lead to an in-depth understanding of the information flow inside the auditory pathway. This will help us to better understand the mechanisms of tinnitus.
Increasing Our Understanding of Avian Hair Cell Regeneration
We provide evidence that in the regenerating basilar papilla, the expression of immune-related genes is tightly controlled, such that four days after damage, they are no longer expressed in newly regenerated hair cells. This is important because the JAK/STAT signaling pathway is highly potent, leading to inflammation, cytokine storms, and fibrosis.
Explanations for Cochlear Implant Hesitancy—and What to Do About It
Despite the benefits of cochlear implantation, adoption is low. Current cochlear implant (CI) usage among adults who are indicated for them is about 5 percent. Uncertainty surrounding the outcome of cochlear implantation drives top patient concerns.
From Reading Faces to Publishing Research
I spent the first 20 years of my life attempting to hide my congenital hearing loss. Like most kids, I just wanted to fit in and be like everyone else, so my younger self could have never predicted that I would have ended up focusing on disability and hearing health within my career.
The Role of Spontaneous Electrical Activity in the Developing Auditory System
Specific ion currents have been identified as major players supporting this electrical activity in developing and regenerating chick hair cells. This research details the role of small-conductance, calcium-ion-activated potassium channels (SK) in developing and regenerating chick hair cells.
Harnessing the Power of Tinnitus Patients’ Experiences
I learned that little was known about the mechanisms causing tinnitus, and treatments were hard to test because they seemed to have very different effects on different people. Researchers call this heterogeneity, and it simply means that your tinnitus is likely different from mine.
Honokiol Presents a Potential Paradigm Shift for Reducing Cisplatin Ototoxicity
We expect a paradigm shift in cisplatin chemotherapy based on the current study and future clinical trials, where honokiol is applied to reduce side effects including hearing loss.
Limited Clinical Utility of Auditory Brainstem Responses for Detecting Tinnitus in Humans
Despite the small sample size and diverse tinnitus population, the present result suggests that the clinical utility of conventional ABR measurement is limited in detecting tinnitus in humans.