chick model

A Protocol for Investigating Hair Cell Regeneration in Birds

The avian inner ear can naturally regenerate sensory hair cells and is therefore an ideal candidate for investigating mechanisms leading to hair cell regeneration and functional recovery.

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Driven by Data and Collaboration

The collaborative spirit of our Hearing Restoration Project consortium is especially evident as we work together to complete a publication describing our analysis of hair cell gene expression.

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Cell-Type Identity of the Chick Balance Organ

We have now identified the first events that lead to proliferative hair cell regeneration in birds, which provides new leads that can be translated to mice and ultimately to humans.

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Increasing Our Understanding of Avian Hair Cell Regeneration   

We provide evidence that in the regenerating basilar papilla, the expression of immune-related genes is tightly controlled, such that four days after damage, they are no longer expressed in newly regenerated hair cells. This is important because the JAK/STAT signaling pathway is highly potent, leading to inflammation, cytokine storms, and fibrosis.

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The Role of Spontaneous Electrical Activity in the Developing Auditory System

Specific ion currents have been identified as major players supporting this electrical activity in developing and regenerating chick hair cells. This research details the role of small-conductance, calcium-ion-activated potassium channels (SK) in developing and regenerating chick hair cells.

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