I currently work with a mouse model with hearing fluctuation and have a clinical protocol that is performing deep phenotyping of patients with hearing instability, including patients with Ménière’s disease.
Shouting From the Rooftops
Putting the Brakes on Hyperactivity in the Brain
The road to more effective, less invasive, and faster developing treatments for tinnitus and loudness hyperacusis lies in focusing on the brain and not the ear.
More Like a Boost
Regrowing Hair Cells and Nerve Connections to Restore Hearing in Birds
This suggests that birds maintain a precise program for hair cell regeneration that preserves frequency-specific nerve connections, which is an important aspect of proper functional recovery.
Lucky to Be Different
What We Can Learn From the Eclipse
Understanding Pain Signals Triggered by Damage to the Inner Ear
Of relevance to hyperacusis, prior noise-induced hearing loss leads to the generation of prolonged and repetitive activity in type II neurons and surrounding tissues. This aberrant signaling may be the basis for the sensitivity to everyday sounds seen in hyperacusis.
Hearing With Humor
Surprising Role of Auditory Neurons in Learning Revealed by Study in Mice
These findings suggest that the auditory cortex may transmit significant non-auditory signals relevant for learning-related plasticity.