endolymphatic hydrops

Meeting Patients Inspires Approach to Treating Ménière’s Disease

I currently work with a mouse model with hearing fluctuation and have a clinical protocol that is performing deep phenotyping of patients with hearing instability, including patients with Ménière’s disease.

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Understanding Inner Ear Fluid Buildup in Ménière’s Disease

Fluid buildup in the saccule and cochlear duct might be due to increased pressure, while the utricle might be better protected due to its thicker walls and functioning valve. This points to an inverse relationship between membrane thickness and fluid buildup, helping us better understand how fluid buildup occurs in Ménière's disease.

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An Explanation for Divergent Test Results in Ménière’s Disease

We also found that the size of the semicircular canal in some Ménière's disease ears was smaller than the control ears. This suggests that the relative size of the inner ear structures may play a role in the development of the condition

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A Historical Perspective on Surgery to Treat Ménière’s Disease

Since it was first discovered, Ménière’s disease has been a disorder managed primarily by otolaryngologists. As a result, surgical treatments have accompanied attempts at medical management. Inspired by patients' sensations of ear fullness and later by the histologic findings of hydrops, surgeons began manipulating the membranous labyrinth to relieve episodes of vertigo while attempting to preserve hearing.

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CT Imaging as a Diagnostic Tool for Ménière’s Disease

Comparing the angle measurements of the ATVA, we confirmed the results of the cadaveric study. There was a strong correlation between late onset Ménière’s with a typical “adult” course of the vestibular aqueduct, while early onset Ménière’s was associated with a more straight, “fetal” course of the vestibular aqueduct.

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