In the aging model, we explored neuronal alterations in the auditory brainstem and reproduced changes observed in aged gerbils. These results suggest that the model can help identify possible neural explanations for changes in hearing test results.
A Breakthrough Protocol for Generating Functional Human Auditory Neurons
The resulting SGN-like neurons matched the appearance, molecular structure, electrical behavior, and functional characteristics of SGN cells in vivo.
Not All Neurons Are Created Equal
Understanding how internal state interacts with cell-type-specific circuits in the auditory cortex may ultimately help identify therapeutic targets for tinnitus and related hearing disorders.
Study Maps Brain’s Ability to Comprehend Sound
New research reveals the unique patterns of gene expression in specific neurons in the brain that process the signals of sound and enable communication.
Analysis of Six Gene Delivery Methods in the Mouse Model
By understanding which AAV serotype works best for delivering genetic instructions to specific brain cells and sharing this information in an open-access journal, researchers can design better experiments and potentially develop treatments for brain-related conditions.
Sound Encoding in the Auditory Midbrain
While individual neurons in the auditory midbrain may not accurately convey information about sound features, the collective activity of these neurons accurately represents sounds.
Putting the Brakes on Hyperactivity in the Brain
The road to more effective, less invasive, and faster developing treatments for tinnitus and loudness hyperacusis lies in focusing on the brain and not the ear.
Surprising Role of Auditory Neurons in Learning Revealed by Study in Mice
These findings suggest that the auditory cortex may transmit significant non-auditory signals relevant for learning-related plasticity.
How Neurons in the Brain Coordinate Movement and Prevent Falls
Activity by special neurons called unipolar brush cells reveals that they may introduce delays or increase the length of firing responses, and presumably extend vestibular sensory representations.
Brain Connectivity Patterns in Children With Autism Spectrum Disorder
Individuals with autism spectrum disorder had different patterns of brain connectivity between areas involved in speech processing, particularly in the parietal region, which is important for combining different sounds into speech objects.