Serotonin seems to quiet down excitatory neurons while boosting inhibitory ones. This differential modulation may help us to understand the role of serotonin in auditory disorders such as tinnitus and age-related hearing loss.
Mass Spectrometry Imaging Reveals Effect of Blasts on Neurotransmitter Levels in the Chinchilla Model
To date there are no clear, definitive management recommendations for tinnitus, whether non-pharmacological or pharmacological. This is mainly due to a poor understanding of the pathomechanism (causes) of tinnitus. An imbalance in the excitation and inhibition of neurotransmitters is implicated, but more research is warranted.