Edward L. Bartlett, Ph.D., Purdue University
Research Topic: Cellular bases of temporal auditory processing
Long-Term Goal: To predict and redevelop the cellular dynamics that underlie in vivo responses of auditory thalamic and auditory cortical neurons in normal and pathological conditions, including age-related decline, dyslexia, and aberrant auditory experience during development.
Published Research
Suppressing Fear in the Presence of a Safety Cue Requires Infralimbic Cortical Signaling to Central Amygdala, Neuropsychopharmacology, 2023.
Comparison of Age-Related Declines in Behavioral Auditory Responses versus Electrophysiological Measures of Amplitude Modulation, Neurobiology of Aging, 2022.
Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus, The Journal of Physiology, 2021.
In vivo whole-cell recordings of stimulus-specific adaptation in the inferior colliculus, Hearing Research, 2020.
Post-stimulatory activity in primate auditory cortex evoked by sensory stimulation during passive listening, Scientific Reports, 2020.
Aging alters envelope representations of speech-like sounds in the inferior colliculus, Neurobiology of Aging, 2019.
Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation, Neuroscience, 2019.
Top-down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons, The Journal of Physiology, 2019.
Masking Differentially Affects Envelope-following Responses in Young and Aged Animals, Neuroscience, 2018.
Community-Building Framework for Collaborative Research Coordination across the Education and Biology Research Disciplines, CEB Life Sciences Education, 2018.
Aging affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons, Journal of Neuroscience, 2017.
Differences in postinjury auditory system pathophysiology after mild blast and nonblast acute acoustic trauma, Journal of Neurophysiology, 2017.
Age-related changes in envelope-following responses at equalized peripheral or central activation, Neurobiology of Aging, 2017.
Hierarchical winner-take-all particle swarm optimization social network for neural model fitting, Journal of Computational Neuroscience, 2017.
Label-Free Vibrational Spectroscopic Imaging of Neuronal Membrane Potential, The Journal of Physical Chemistry Letters, 2017.
Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss, Ear and Hearing, 2017.
Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses, European Journal of Neuroscience, 2016.
Age-related shifts in distortion product otoacoustic emissions peak-ratios and amplitude modulation spectra, Hearing Research, 2016.
Postnatal development of auditory central evoked responses and thalamic cellular properties, Developmental Biology, 2014
Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus, Journal of Neurophysiology, 2013
The organization and physiology of the auditory thalamus and its role in processing acoustic features important for speech perception, Brain and Language, 2013.
A Computational Model of Inferior Colliculus Responses to Amplitude Modulated Sounds in Young and Aged Rats, Frontiers in Neural Circuits, 2012
Two-channel recording of auditory-evoked potentials to detect age-related deficits in temporal processing, Hearing Research, 2012.
A computational model of cellular mechanisms of temporal coding in the medial geniculate body, PLOS One, 2011
NIH & Other Major Federal Research Funding: $2,050,935
Interdisciplinary Training in Auditory Neuroscience, NIDCD, $153,329 awarded in 2023.
Rapid Triage of Auditory Peripheral and Central Phenotypes Using a Brief but Rich Diagnostic Battery, CDMRP, $332,367 awarded in 2020.
Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $379,509 awarded in 2016.
Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $365,550 awarded in 2015.
Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $370,804 awarded in 2014.
Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $317,026 awarded in 2013.
Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $285,679 awarded in 2012.
Brenton G. Cooper, Ph.D., Texas Christian University
Research Topic: Lateralization of acoustic perception in Bengalese finches
Long-Term Goal: To develop an animal model for testing and refining treatments for hearing loss and lateralized frequency processing deficits in humans, including CAPD.
Published Research
Preparing to Sing: Respiratory Patterns Underlying Motor Readiness for Song, Journal of Neurophysiology, 2022.
Intraventricular Murine Aβ Infusion Elicits Hippocampal Inflammation and Disrupts the Consolidation, but not Retrieval, of Conditioned Fear in C57BL6/J Mice, Behavioural Brain Research, 2020.
Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior, eLife, 2019.
Differential patterns of constant frequency 50 and 22 khz usv production are related to intensity of negative affective state, Behavioral Neuroscience, 2017.
HVC contributes toward conspecific contact call responding in male Bengalese finches, Neuroreport, 2016.
Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure, Behavioural Brain Research, 2013.
Laryngeal aging and acoustic changes in male rat ultrasonic vocalizations, Developmental Psychology, 2013.
Exploring vocal recovery after cranial nerve injury, Neuroscience Letters, 2013.
Syringeal specialization of frequency control during song production in the Bengalese finch (Lonchura striata domestica), PloS One, 2012.
Age-related changes in the Bengalese finch song motor program, Neurobiology of Aging, 2012.
NIH & Other Major Federal Research Funding: $3,088,757
Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $642,204 awarded in 2022.
Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $667,697 awarded in 2021.
Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $578,247 awarded in 2020.
Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $573,872 awarded in 2019.
Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $626,737 awarded in 2018.
Zhengqing Hu, M.D., Ph.D., Wayne State University School of Medicine
Research Topic: Innervation of in vitro-produced hair cell by neural progenitor-derived glutamatergic neurons
Long-Term Goal: To develop effective strategies to regenerate auditory pathways using stem cell-based approaches to restore hearing. If successful, the research will then explore whether stem cell-derived cells can be used to regenerate auditory cells damaged in CAPD.
Published Research
Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model, Frontiers in Cellular Neuroscience, 2022.
Generation of a Spiral Ganglion Neuron Degeneration Mouse Model, Frontiers in Cell and Developmental Biology, 2021.
Insights into the molecular mechanisms regulating mammalian hair cell regeneration, Current Opinion in Otolaryngology & Head and Neck Surgery, 2021.
Generation of Cochlear Hair Cells from Sox2 Positive Supporting Cells via DNA Demethylation, International Journal of Molecular Sciences, 2020.
Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model, Scientific Reports, 2019.
Identification of Neural Stem Cells from Postnatal Mouse Auditory Cortex In Vitro, Stem Cells and Development, 2019.
Aligned contiguous microfiber platform enhances neural differentiation of embryonic stem cells, Scientific Reports, 2018.
Embryonic Stem Cell-Derived Peripheral Auditory Neurons Form Neural Connections with Mouse Central Auditory Neurons In Vitro via the α2δ1 Receptor, Stem Cell Reports, 2018.
Expression of Oligodendrocyte Marker during Peripheral-Central Transitional Zone Formation of the Postnatal Mouse Cochlear Nerve, Otolaryngology–Head and Neck Surgery, 2017
Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy, Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2017.
Stimulation of synapse formation between stem cell-derived neurons and native brainstem auditory neurons, Scientific Reports, 2017
Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons, Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2017.
Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells, Frontiers in Cellular Neuroscience, 2016.
Genome-wide demethylation by 5-aza-2'-deoxycytidine alters the cell fate of stem/progenitor cells, Stem Cell Reviews and Reports, 2015.
The astroglial reaction along the mouse cochlear nerve following inner ear damage, Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells, Cellular Reprogramming, 2014.
The potential of stem cells for the restoration of auditory function in humans, Future Medicine, 2013.
Sensory Epithelial Cells Acquire Features of Prosensory Cells Via Epithelial to Mesenchymal Transition, Stem Cells and Development, 2012.
Concentration-dependent effect of NGF on cell fate determination of neural progenitor, Stem Cells and Development, 2011.
NIH & Other Major Federal Research Funding: $3,008,170
Developing Novel Stem Cell-Based Epigenetic Approaches to Treat Hearing Loss, VA, $1,100,000 awarded in 2018–2023.
Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2018.
Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2017.
Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2016.
Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $319,770 awarded in 2015.
Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2014.
Reconstruction of the Ascending Neural Circuit from the Spiral Ganglion, NIDCD, $144,400 awarded in 2013.
Reconstruction of the Ascending Neural Circuit from the Spiral Ganglion, NIDCD, $152,000 awarded in 2012.
Erin K. Purcell, Ph.D., University of Michigan
Research Topic: A stem cell-seeded nanofibrous scaffold for auditory nerve regeneration
Long-Term Goal: To regenerate auditory nerves and understand the conditions that promote neural connections with the auditory brainstem, in order to ultimately restore hearing for patients with neural hearing loss and find for therapies for individuals with CAPD.
Published Research
Structural and Functional Changes of Deep Layer Pyramidal Neurons Surrounding Microelectrode Arrays Implanted in Rat Motor Cortex, Acta Biomaterialia, 2023.
In Vitro Biofouling Performance of Boron-Doped Diamond Microelectrodes for Serotonin Detection Using Fast-Scan Cyclic Voltammetry, Biosensors, 2023.
Spatiotemporal expression of RNA-seq identified proteins at the electrode interface, Acta Biomaterialia, 2023.
Atomic Force Microscope Characterization of the Bending Stiffness and Surface Topography of Silicon and Polymeric Electrodes, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2022.
Differential Co-Expression Analysis of RNA-Seq Data Reveals Novel Potential Biomarkers of Device-Tissue Interaction, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2022.
Spatial Transcriptomics as a Novel Approach to Redefine Electrical Stimulation Safety, Frontiers in Neuroscience, 2022.
Spatiotemporal patterns of gene expression around implanted silicon electrode arrays, Journal of Neuroengineering, 2020.
Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities, Micromachines, 2021.
Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system, Journal of Neuroengineering, 2020.
Flexible, diamond-based microelectrodes fabricated using the diamond growth side for neural sensing, Microsystems & Nanoengineering, 2020.
Differentiation and characterization of neurons derived from rat iPSCs, Journal of Neuroscience Methods, 2020.
Pipette-integrated microelectrodes, Nature Biomedical Engineering, 2019.
Neuroethical considerations of high-density electrode arrays, Nature Biomedical Engineering, 2019.
Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface, Journal of Neural Engineering, 2018.
Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications, Micromachines, 2018.
Publisher Correction: Glial responses to implanted electrodes in the brain, Nature Biomedical Engineering, 2018.
Ultracompact Microwatt CMOS Current Readout With Picoampere Noise and Kilohertz Bandwidth for Biosensor Arrays, IEEE transactions on biomedical circuits and systems, 2018.
Glial responses to implanted electrodes in the brain, Nature Biomedical Engineering, 2017.
Neuronal excitability and network formation on optically transparent electrode materials, International IEEE/EMBS Conference on Neural Engineering: [proceedings]. International IEEE EMBS Conference on Neural Engineering, 2017.
Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses, Journal of Neurophysiology, 2017.
Regenerative Electrode Interfaces for Neural Prostheses, Tissue Engineering. Part B, Reviews, 2016.
BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells, Stem Cell Research, 2013.
Combining topographical and genetic cues to promote neuronal fate specification in embryonic stem cells, Biomacromolecules, 2012.
NIH & Other Major Federal Research Funding: $3,185,243
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $347,024 awarded in 2023.
Spatial transcriptomics at the interface of implanted electrodes in the brain, NINDS, $156,248 awarded in 2022.
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $347,024 awarded in 2022.
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $372,599 awarded in 2021.
Genetic approaches to establish design rules for implantable neurotechnology, NSF, $543,269 awarded in 2020.
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $372,599 awarded in 2020.
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $77,015 awarded in 2019.
Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $402,997 awarded in 2019.
Plasticity in the Electrical Properties of Neurons Surrounding Neuroprostheses, NINDS, $187,067 awarded in 2017.
Plasticity in the Electrical Properties of Neurons Surrounding Neuroprostheses, NINDS, $225,901 awarded in 2016.
Optical Control of Network Formation in Stem Cell-Derived Neurons, NINDS, $76,750 awarded in 2016.
Optical Control of Network Formation in Stem Cell-Derived Neurons, NINDS, $76,750 awarded in 2015.