David Martinelli, Ph.D., University of Connecticut Health Center
Research topic: Development and transmission of the tinnitus neural code
Long-term goal: To understand how tinnitus is encoded by the auditory system. This will reveal novel therapeutic targets (e.g., specific circuits or optimal time for intervention) for treating tinnitus.
Published Research
Backbone resonance assignment of the pentraxin domain of the neuronal pentraxin receptor (NPTXR), Biomolecular NMR Assignments, 2025.
C1ql3 promotes cognitive flexibility behavior in mice, Neuroscience Letters, 2025.
C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation, The FEBS Journal, 2025.
Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells, Nature Neuroscience, 2025.
Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses, FEBS Letters, 2024.
C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient, PLoS One, 2021.
C1QL3 promotes cell-cell adhesion by mediating complex formation between ADGRB3/BAI3 and neuronal pentraxins, Neural Plasticity, 2021.
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis, Cell Stem Cell, 2020.
NIH & Other Major Federal Funding: $1,148,000
Determination of the subcellular localization of adhesion G protein-coupled receptor B3 (ADGRB3) and its locations of interaction with secreted C1Q-like ligands, NIDCD, $164,000 awarded 2020.
A novel signaling pathway to promote oligodendrocyte maturation leading to a new treatment for multiple sclerosis, CDMRP, $984,000 awarded 2020.