Senthilvelan Manohar, Ph.D., University at Buffalo
Research topic: Behavioral model of loudness intolerance
Long-term goal: To develop and establish a reliable behavioral model to understand the pain and annoyance aspects of hyperacusis and touse these behavioral models to identify the neural and molecular mechanisms underlying hyperacusis and tinnitus.
Published Research
Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance, Cerebral Cortex, 2025.
Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons, Scientific Reports, 2024.
Chronic Stress Induced Loudness Hyperacusis, Sound Avoidance and Auditory Cortex Hyperactivity, Hearing Research, 2023.
Galectin-3 protects auditory function in female mice, Hearing Research, 2022.
A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communication, PLoS Genetics, 2022.
Unexpected consequences of noise-induced hearing loss: Impaired hippocampal neurogenesis, memory, and stress, Frontiers in Integrative Neuroscience, 2022.
Time- and frequency-dependent changes in acoustic startle reflex amplitude following cyclodextrin-induced outer and inner cell loss, Hearing Research, 2022.
Combined antioxidants and anti-inflammatory therapies fail to attenuate the early and late phases of cyclodextrin-induced cochlear damage and hearing loss, Hearing Research, 2022.
Blast trauma affects production and perception of mouse ultrasonic vocalizations, The Journal of the Acoustical Society of America, 2022.
Spatiotemporal developmental upregulation of prestin correlates with the severity and location of cyclodextrin-induced outer hair cell loss and hearing loss, Frontiers in Cell and Developmental Biology, 2021.
Roles of Bak and Sirt3 in paraquat-induced cochlear hair cell damage, Neurotoxicity Research, 2021.
Review: Neural mechanisms of tinnitus and hyperacusis in acute drug-induced ototoxicity, American Journal of Audiology, 2021.
Loss of CX3CR1 augments neutrophil infiltration into cochlear tissues after acoustic overstimulation, Journal of Neuroscience Research, 2021.
Long term changes to auditory sensitivity following blast trauma in mice, Hearing Research, 2021.
Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome, Neurobiology of Disease, 2021.
New insights on repeated acoustic injury: Augmentation of cochlear susceptibility and inflammatory reaction resultant of prior acoustic injury, Hearing Research, 2020.
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling, Hearing Research, 2020.
Hydroxypropyl-β-cyclodextrin causes massive damage to the developing auditory and vestibular system, Hearing Research, 2020.
Dynamic changes in synaptic plasticity genes in ipsilateral and contralateral inferior colliculus following unilateral noise-induced hearing loss,s Neuroscience, 2020.
Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory, Hearing Research, 2020.
Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats, Hearing Research, 2019.
GSTA4 mediates reduction of cisplatin ototoxicity in female mice, Nature Communications, 2019.
Species differences in the organization of the ventral cochlear nucleus, Anatomical Record, 2018.
Hidden age-related hearing loss and hearing disorders: Current knowledge and future directions, Hearing, Balance and Communication, 2018.
Jennifer Resnik, Ph.D., Mass Eye and Ear
Research topic: Homeostatic modifications in cortical GABA circuits enable states of hyperexcitability and reduced sound level tolerance after auditory nerve degeneration
Long-term goal: To better understand the paradoxical role of central auditory system plasticity as both the cause of—and treatment for—the perceptual consequences of hearing loss. A major step to reach this goal is to understand the compensatory mechanisms, following cochlear damage, that allow for basic sound recovery while potentially introducing hypersensitivity and causing chronic sensory impairments such as hyperacusis.
Published Research
Repetitive stress decreases norepinephrine's dynamic range in the auditory cortex, Neuropharmacology, 2025.
Repeated stress gradually impairs auditory processing and perception, PLoS Biology, 2025.
Experience-driven development of decision-related representations in the auditory cortex, EMBO Reports, 2025.
Impaired folate metabolism reshapes auditory response profiles and impairs loudness perception in MTHFR-deficient mice, Neurobiology of Disease, 2025.
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise, Neuron, 2021.
Cellular and widefield imaging of sound frequency organization in primary and higher order fields of the mouse auditory cortex, Cerebral Cortex, 2020.
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders, Nature Communications, 2019.