Brad Buran, Ph.D., Oregon Health & Science University
Research topic: Neural mechanisms of hyperacusis in the inferior colliculus and cortex of ferrets with noise-induced auditory neurodegeneration
Long-term goal: To understand how hearing loss alters central auditory system function and how this abnormal function can be ameliorated to improve auditory outcomes.
Published Research
Predicting Cochlear Synaptopathy in Mice with Varying Degrees of Outer Hair Cell Dysfunction Using Auditory Evoked Potentials, Journal of the Association for Research in Otolaryngology, 2025.
Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms, Hearing Research, 2025.
ABRpresto: An algorithm for automatic thresholding of the Auditory Brainstem Response using resampled cross-correlation across subaverages, Hearing Research, 2025.
Associations Between Physiological Correlates of Cochlear Synaptopathy and Tinnitus in a Veteran Population, Journal of Speech, Language and Hearing Research, 2023.
Predicting synapse counts in living humans by combining computational models with auditory physiology, The Journal of the Acoustical Society of America, 2022.
Supporting equity and inclusion of deaf and hard-of-hearing individuals in professional organizations, Frontiers in Education, 2021.
Streaming of repeated noise in primary and secondary fields of auditory cortex, The Journal of Neuroscience, 2020.
Pupil-associated states modulate excitability but not stimulus selectivity in primary auditory cortex, Journal of Neurophysiology, 2020.
Optimizing auditory brainstem response acquisition using interleaved frequencies, Journal of the Association for Research in Otolaryngology, 2020.
Community network for deaf scientists, Science, 2017.
NIH & Other Major Federal Funding: $512,797
Consequences of cochlear synaptopathy on signal detection in noisy environments: perception and central auditory processing, NIDCD, $168,784 awarded in 2020.
Consequences of cochlear synaptopathy on signal detection in noisy environments: perception and central auditory processing, NIDCD, $168,784 awarded in 2019.
Consequences of cochlear synaptopathy on signal detection in noisy environments: perception and central auditory processing, NIDCD, $21,229 awarded in 2018.
Consequences of cochlear synaptopathy on signal detection in noisy environments: perception and central auditory processing, NIDCD, $154,000 awarded in 2018.
Kelly Radziwon, Ph.D., University at Buffalo
Research topic: The relationship between pain-related molecules in the auditory pathway and hyperacusis
Long-term goal: To broaden our understanding of the neural mechanisms underlying loudness perception in order to find a potential therapeutic target to correct, or mitigate, bothersome hyperacusis.
Published Research
Review: Neural mechanisms of tinnitus and hyperacusis in acute drug-induced ototoxicity, American Journal of Audiology, 2021.
Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome, Neurobiology of Disease, 2021.
Using auditory reaction time to measure loudness growth in rats, Hearing Research, 2020.
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling, Hearing Research, 2020.
Functional magnetic resonance imaging of enhanced central auditory gain and electrophysiological correlates in a behavioral model of hyperacusis, Hearing Research, 2020.
Testing the central gain model: Loudness growth correlates with central auditory gain enhancement in a rodent model of hyperacusis, Neuroscience, 2019.
Psychophysical changes in temporal processing in chinchillas with noise-induced hearing loss: A literature review, The Journal of the Acoustical Society of America, 2019.
Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala, Neuroscience, 2019.
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress, Hearing Research, 2017.
Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects, Hearing Research, 2017.
Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain, Frontiers in Neuroscience, 2016.
Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling, Molecular and Cellular Neuroscience, 2016.
Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice, Hearing Research, 2016.