Xiying Guan, Ph.D., Mass Eye and Ear
Research topic: Hyperacusis caused by abnormalities in auditory mechanics
Long-term goal: To understand how hyperacusis can occur due to mechanical disturbances of the middle and inner ear, and to provide the necessary scientific understanding to enable treatment.
Published Research
A case of acquired amusia and misophonia following right temporal resection, Hearing Research, 2026.
Non-contact optical stiffness measurements in the organ of Corti in mice, Hearing Research, 2025.
A mechanical lumped-element model of the human middle ear for bone conduction hearing, Scientific Reports, 2025.
The impact of size on middle-ear sound transmission in elephants, the largest terrestrial mammal, PLoS One, 2024.
Superior canal dehiscence similarly affects cochlear pressures in temporal bones and audiograms in patients, Ear & Hearing, 2020.
Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism, Scientific Reports, 2020.
PVDF-based piezoelectric microphone for sound detection inside the cochlea: Toward totally implantable cochlear implants, Trends in Hearing, 2018.
Intracochlear sound pressure measurements in normal human temporal bones during bone conduction stimulation, Journal of the Association for Research in Otolaryngology: JARO, 2018.
Impedances of the inner and middle ear estimated from intracochlear sound pressures in normal human temporal bones, Hearing Research, 2018.
Factors affecting sound energy absorbance in acute otitis media model of chinchilla, Hearing Research, 2017.
NIH & Other Major Federal Funding: $496,155
Hyperacusis Caused by Mechanical Abnormalities in the Ear, NIDCD, $22,899 awarded in 2020.
Hyperacusis Caused by Mechanical Abnormalities in the Ear, NIDCD, $133,256 awarded in 2020.
Hyperacusis Caused by Mechanical Abnormalities in the Ear, NIDCD, $170,000 awarded in 2019.
Hyperacusis Caused by Mechanical Abnormalities in the Ear, NIDCD, $170,000 awarded in 2018.