HYPERACUSIS RESEARCH ACOOMPLISHMENTS

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Thanks to the generosity of Hyperacusis Research, Hearing Health Foundation (HHF) funds groundbreaking research to advance our scientific understanding of hyperacusis and loudness intolerance.

Grants focused on hyperacusis are awarded annually to promising scientific investigators through the Emerging Research Grants (ERG) program.

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HYPERACUSIS RESEARCH ACCOMPLISHMENTS BY HHF-FUNDED SCIENTISTS

Kelly Radziwon, Ph.D., and Senthilvelan Manohar, Ph.D., measured noise-induced changes in the expression (amount) of genes involved in the synthesis of proteins known to be involved in neuropathic pain and neuro-inflammation. Interestingly, the researchers found that intense noise exposure significantly altered the expression of six genes (Ccl12, Tlr2, Oprd1, II1b, Ntrk1 & Kcnq3) in the cochlear nucleus. These results suggest that noise-induced inflammation in the parts of the central auditory pathway that also processes sensory information related to pain might, in turn, activate the central pain pathway thus producing ear pain. Learn more.

Kelly Radziwon, Ph.D., and Senthilvelan Manohar, Ph.D., observed that stress may interact with hearing loss in tinnitus and hyperacusis development. Exploring two novel non-auditory areas implicated in these conditions, they conclude increased stress response has the potential to have wide-ranging effects on the central nervous system and may therefore contribute to brain-wide changes in neural activity. Learn more.

Xiying Guan, Ph.D, and colleagues assessed an existing treatment for hyperacusis and discovered its negative effects. They tested how inner ear round window (RW) reinforcement affects air-conduction sound transmission in the typical ear. The results suggest that RW reinforcement has the potential to worsen low-frequency hyperacusis while causing some hearing loss in the mid-frequencies. Learn more.

Senthilvelan Manohar, Ph.D., and colleagues have compiled evidence supporting that startle reflex amplitudes may be related to hyperacusis in the elderly. The experiments were conducted using a mouse model for early age-related hearing loss. Learn more.

Kelly Radziwon, Ph.D., and colleague created an animal model of hyperacusis that provides the necessary groundwork for future studies of noise-induced hyperacusis and loudness intolerance. Learn more.