Hearing Health Foundation (HHF) is grateful to Royal Arch Research Assistance (RARA) for their most generous support of Central Auditory Processing Disorder (CAPD) research as part of our Emerging Research Grants (ERG) program. 

Researchers funded by RARA have made tremendous strides toward a better understanding of CAPD, as well as developing treatments and therapies that can benefit anyone affected by the disorder, from children to the elderly.

Many RARA-supported HHF grantees have gone on to receive awards from the following federal institutions:

• NIH (National Institutes of Health) including the NIDCD (National Institutes on Deafness and Other Communication Disorders), the NINDS (National Institute of Neurological Disorders and Stroke), and the NIGMS (National Institute of General Medical Sciences)

• NSF (National Science Foundation)

• CDMRP (Congressionally Directed Medical Research Programs)

• DoD (Department of Defense)

• VA (Veterans Administration)

We are grateful for your investment and trust in our rigorous grant review process. We look forward to continuing our relationship and furthering CAPD research for years to come. Follow the links at right to learn about RARA grantees' projects and accomplishments by year.

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FIRST YEAR

Amanda Griffin, Ph.D., Au.D., Boston Children’s Hospital

Research Topic: Toward better assessment of pediatric unilateral hearing loss

Long-term goal: To enhance basic understanding of auditory and non-auditory function in children with untreated and treated single-sided deafness in order to build evidence-based clinical guidelines for the management of children with single-sided deafness.

HiJee Kang, Ph.D., Johns Hopkins University

Research Topic: Age-related changes on neural mechanisms in the auditory cortex for learning complex sounds

Long-Term Goal: To apply insights from neural dynamics observed in animal models to enhance our understanding of human auditory processing, particularly in the context of aging in order to further development of clinical prostheses that will improve the quality of life for those experiencing age-related hearing challenges.

SECOND YEAR

Carolyn McClaskey, Ph.D., Medical University of South Carolina (see 2023 Grantees)

Melissa Polonenko, Ph.D., University of Minnesota–Twin Cities (see 2023 Grantees)

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FIRST YEAR

Carolyn McClaskey, Ph.D., Medical University of South Carolina

Research Topic: Age and hearing loss effects on subcortical envelope encoding

Long-term goal: To better understand how age and age-related hearing loss alter the neural signaling of the auditory system (specifically the auditory midbrain) and negatively impact speech communication, so that we can work toward developing effective clinical interventions and improving communication for older adults and adults with age-related hearing loss.

Published Research

• Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss, Hearing Research, 2024.

NIH & Other Major Federal Funding: $185,690

• Age and hearing loss effects on subcortical neural encoding, NIDCD, $185,690 awarded in 2023.

Melissa Polonenko, Ph.D., University of Minnesota–Twin Cities

Research Topic: Identifying hearing loss through neural responses to engaging stories

Long-Term Goal: To develop an engaging, objective clinical test that uses stories to identify hearing loss in young children and evaluate changes to their responses to the same speech through hearing aids.

SECOND YEAR

Manoj Kumar, Ph.D., University of Pittsburgh (see 2022 Grantees)

Z. Ellen Peng, Ph.D., Boys Town National Research Hospital (see 2020 Grantees)

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Manoj Kumar, Ph.D., University of Pittsburgh

Research Topic: Signaling mechanisms of auditory cortex plasticity after noise-induced hearing loss

Long-Term Goal: To identify the molecular and cellular therapeutic targets for treating and rehabilitating the impaired hearing associated with tinnitus and hyperacusis.

Published Research

• Cortical zinc signaling is necessary for changes in pupil diameter that are evoked by background sounds with different contrast in mice, The Journal of Neuroscience, 2024.

• Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage, Nature Communications, 2023.

• A CRE/DRE Dual Recombinase Transgenic Mouse Reveals Synaptic Zinc-Mediated Thalamocortical Neuromodulation, Science Advances, 2023.

• A Genetically Encoded Far-Red Fluorescent Indicator for Imaging Synaptically Released Zn2+, Science Advances, 2023.

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2011 Grantees

Z. Ellen Peng, Ph.D., University of Wisconsin-Madison

Research Topic: Investigating cortical processing during comprehension of reverberant speech in adolescents and young adults with cochlear implants

Long-Term Goal: To understand the impact of profound childhood hearing loss treated by cochlear implants on both behavioral outcomes and neural mechanisms involved in understanding speech in adverse auditory environments. This work will add to our knowledge in developing personalized clinical device fitting strategies for children with hearing loss to enhance communication and learning in realistic indoor environments.

Published Research

• Web-based psychoacoustics of binaural hearing: Two validation experiments, The Journal of the Acoustical Society of America, 2023.

• Differences between children and adults in the neural encoding of voice fundamental frequency in the presence of noise and reverberation, The European Journal of Neuroscience, 2023.

• Hearing Preservation and Spatial Hearing Outcomes After Cochlear Implantation in Children With TMPRSS3 Mutations, Otology & Neurotology, 2023.

• Remote testing for psychological and physiological acoustics, The Journal of the Acoustical Society of America, 2022.

• Spatial release from masking in reverberation for school-age children, The Journal of the Acoustical Society of America, 2021.

• Novel Approaches to Measure Spatial Release From Masking in Children With Bilateral Cochlear Implants, Ear & Hearing, 2021.

• The Role of Interaural Differences, Head Shadow, and Binaural Redundancy in Binaural Intelligibility Benefits Among School-Aged Children, Trends in Hearing, 2021.

NIH & Other Major Federal Funding: $405,100

• Development of functional spatial hearing in reverberation, NIDCD, $202,550 awarded in 2023.

• Development of functional spatial hearing in reverberation, NIDCD, $202,550 awarded in 2022.

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Kristi Hendrickson, Ph.D., University of Iowa

Research Topic: Neural correlates of semantic structure in children who are hard of hearing

Long-Term Goal: To identify key factors that influence language outcomes in children who are hard of hearing.

Published Research

• Inhibition of lexical representations after violated semantic predictions, Cognition, 2023.

• Barriers to Equity in Pediatric Hearing Health Care: A Review of the Evidence, Perspectives of the ASHA Special Interest Groups, 2022.

• The Role of Orthography and Phonology in Written Word Recognition: Evidence From Eye-Tracking in the Visual World Paradigm, Journal of Speech, Language, and Hearing Research, 2022.

• School-Age Children Adapt the Dynamics of Lexical Competition in Suboptimal Listening Conditions, Child Development, 2021.

• The Recognition of Whispered Speech in Real-Time, Ear & Hearing, 2021.

• The profile of real-time competition in spoken and written word recognition: more similar than different, Quarterly Journal of Experimental Psychology, 2021.

• Visual and haptic responses as measures of word comprehension and speed of processing in toddlers: Relative predictive utility, Journal of Experimental Child Psychology, 2020.

• Cognitive processes underlying spoken word recognition during soft speech, Cognition, 2020.

NIH & Other Major Federal Funding: $1,320,178

• Language outcomes, mechanisms, and trajectories in adults with and without Developmental Language Disorder, NIDCD, $573,686 awarded in 2023.

• Language outcomes, mechanisms, and trajectories in adults with and without Developmental Language Disorder, NIDCD, $581,183 awarded in 2022.

• Word recognition in dual language learners: The mechanisms underlying listening and reading in two languages, NICHD, $75,957 awarded in 2022.

• Word recognition in dual language learners: The mechanisms underlying listening and reading in two languages, NICHD, $89,352 awarded in 2021.

Hao Luo, M.D., Ph.D., Wayne State University

Research Topic: Cochlear electrical stimulation–induced tinnitus suppression and related neural activity change in the rat inferior colliculus

Long-Term Goal: To find the underlying mechanism by which CES alters neural activity to effect changes in auditory symptoms and perceptions and to develop an optimal strategy to improve clinical trials in this area.

Published Research

• Contributions of Hearing Loss and Traumatic Brain Injury to Blast-Induced Cortical PV Neuron Loss and Auditory Processing Deficits, Journal of Neurotrauma, 2022.

• Using Time Difference Analysis Algorithms to Measure the Response Time of Rat Auditory Cortex Neurons to Auditory Nerve Stimulation, Measurement and Control, 2022.

• Brain Hemispheres Swap Dominance for Processing Semantically Meaningful Pitch, Frontiers in Human Neuroscience, 2021.

• Neuroinflammation and Tinnitus, Current Topics in Behavioral Neurosciences, 2021.

• Evaluating Auditory Neural Activities and Information Transfer Using Phase and Spike Train Correlation Algorithms, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2020.

Vijaya Prakash Krishnan Muthaiah, Ph.D., University at Buffalo, the State University of New York

Research Topic: Potential of inhibition of poly ADP-ribose polymerase as a therapeutic approach in blast-induced cochlear and brain injury

Long-Term Goal: To determine the mechanisms underlying both the peripheral and central aspects of blast-induced auditory neurodegeneration; and to identify and characterize potential therapeutic targets for manifestations of blast-induced traumatic brain injury, including hearing loss, cochlear synaptopathy, tinnitus, and associated deficits.

Published Research

• Disabling tinnitus and third nerve palsy following pontine hemorrhage: Application of ICF framework, Clinical Case Reports, 2024.

• Mitochondrial Dysfunction and Apoptosis in Brain Microvascular Endothelial Cells Following Blast Traumatic Brain Injury, Cellular and Molecular Neurobiology, 2023.

• Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury, Quantitative Imaging in Medicine and Surgery, 2023.

• The Influence of Motoric Maneuvers on Cervical Vestibular Evoked Myogenic Potentials (cVEMPs), Journal of the American Academy of Audiology, 2022.

• Cross-species experiments reveal widespread cochlear neural damage in normal hearing, Communications Biology, 2022.

• Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease, Journal of Cerebral Blood Flow & Metabolism, 2022.

• Molecular docking analysis of glycogen phosphorylase with inhibitors from Cissampelos pareira Linn., Bioinformation, 2022.

• Vestibular Cochlear Manifestations in COVID-19 Cases, Frontiers in Neurology, 2022.

• Blast-induced injury responsive relative gene expression of traumatic brain injury biomarkers in human brain microvascular endothelial cells, Brain Research, 2021.

• Correlation of histomorphometric changes with diffusion tensor imaging for evaluation of blast-induced auditory neurodegeneration in chinchilla, Journal of Neurotrauma, 2021.

• Mass spectrometry imaging of blast overpressure induced modulation of GABA/glutamate levels in the central auditory neuraxis of Chinchilla, Experimental and Molecular Pathology, 2021.

NIH & Other Major Federal Research Funding

• Behavioral evidence of tinnitus and its correlation with ABR wave metrics in chinchilla induced by blast injury. Funded by the Department of Defense, Department of the Army–Army Research Office, 2020, amount undisclosed.

William “Jason” Riggs, Au.D., The Ohio State University

Research Topic: Electrophysiological characteristics in children with auditory neuropathy spectrum disorder

Long-Term Goal: To use objective techniques to further target and investigate physiologic properties of the auditory system, which can be used to better understand the underlying lesion/impairment; and to improve clinical cochlear implant mapping strategies for children with ANSD through the information gleaned from objective electrophysiologic testing.

Published Research

• Post-operative evaluation of computed tomography imaging following cochlear implantation, American Journal of Otolaryngology, 2023.

• Noise-Induced Hearing Loss in the Contralateral Ear During Otologic and Neurotologic Surgeries, American Journal of Otolaryngology, 2023.

• The Natural History, Clinical Outcomes, and Genotype-Phenotype Relationship of Otoferlin-Related Hearing Loss: A Systematic, Quantitative Literature Review, Human Genetics, 2023.

• Assessment of Cochlear Synaptopathy by Electrocochleography to Low Frequencies in a Preclinical Model and Human Subjects, Frontiers in Neurology, 2023.

• Lack of Neural Contributions to the Summating Potential in Humans with Ménière's Disease, Frontiers in Neuroscience, 2022.

• Can Electrocochleography Help Preserve Hearing After Cochlear Implantation With Full Electrode Insertion?, Otology & Neurotology, 2022.

• Characterizing Electrophysiological Response Properties of the Peripheral Auditory System Evoked by Phonemes in Normal and Hearing Impaired Ears, Ear & Hearing, 2022.

• Neural Adaptation of the Electrically Stimulated Auditory Nerve Is Not Affected by Advanced Age in Postlingually Deafened, Middle-aged, and Elderly Adult Cochlear Implant Users, Ear & Hearing, 2022.

• The Effect of Advanced Age on the Electrode-Neuron Interface in Cochlear Implant Users, Ear & Hearing, 2022.

• Automated Calculation of Cochlear Implant Electrode Insertion Parameters in Clinical Cone-Beam CT, Otology & Neurotology, 2021.

• Relationship Between Intraoperative Electrocochleography and Hearing Preservation, Otology & Neurotology, 2021.

• The Sensitivity of the Electrically Stimulated Auditory Nerve to Amplitude Modulation Cues Declines With Advanced Age, Ear & Hearing, 2021.

• Intraoperative Electrocochleography in Subjects Affected by Vestibular Schwannoma and Meniere's Disease: Comparison of Results, Ear & Hearing, 2021.

• Electrocochleography and Cochlear Implantation: A Systematic Review. [Review], Otology & Neurotology, 2020.

• Intraoperative Monitoring of Auditory Function During Lateral Skull Base Surgery. [Miscellaneous Article], Otology & Neurotology, 2020.

• Utilizing Electrocochleography as a Microphone for Fully Implantable Cochlear Implants, Scientific Reports, 2020.

• Effect of Increasing Pulse Phase Duration on Neural Responsiveness of the Electrically Stimulated Cochlear Nerve, Ear & Hearing, 2020.

• Prediction of the Functional Status of the Cochlear Nerve in Individual Cochlear Implant Users Using Machine Learning and Electrophysiological Measures, Ear & Hearing, 2020.

• Electrocochleography During Translabyrinthine Approach for Vestibular Schwannoma Removal, Otology & Neurotology, 2020.

• Recommendations for Measuring the Electrically Evoked Compound Action Potential in Children With Cochlear Nerve Deficiency, Ear & Hearing, 2020.

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2011 Grantees

Alisha Lambeth Jones, Au.D., Ph.D., Auburn University 

Research topic: Evaluating central auditory processing (CAP), language, and cognition skills in adolescents born prematurely

Long-Term Goal: To identify patterns of deficits in auditory processing, language, and cognition skills for both children and adolescents with a premature birth history. Once patterns of deficits are identified, early intervention treatment as well as a rehabilitation program will be developed to either prevent or treat the deficit areas.

Published Research

• Acceptable Noise Levels Determined by Traditional and Self-Assessed Methods, Journal of the American Academy of Audiology, 2021.

• Prematurity and the Auditory System: Considerations for Audiologists, The Hearing Journal, 2020.

Elliott Kozin, M.D., Mass. Eye and Ear, Harvard University

Research Topic: Evaluation of hearing loss and quality of life in patients with mild traumatic brain injury

Long-Term Goal: To better diagnose and treat patients with auditory dysfunction following head injury, thereby minimizing hearing loss, tinnitus, and hyperacusis. The study has implications for a broad range of individuals, including those with isolated head injuries as well as those with repetitive head injuries, such as athletes and military personnel.

Published Research

• Human otopathology in scleroderma, Laryngoscope Investigative Otolaryngology, 2023.

• Design of medical tympanostomy conduits with selective fluid transport properties, Science Translational Medicine, 2023.

• Educational Quality of YouTube Cholesteatoma Surgery Videos: Areas for Improvement, OTO open, 2022.

• Evaluating the accuracy of speech to text applications for cochlear implant candidates during COVID-19, Cochlear Implants International, 2022.

• Otopathologic and Computed Tomography Correlation of Internal Auditory Canal Diverticula in Otosclerosis, Otology & Neurotology, 2022.

• Information scarcity among otolaryngology applicants: A review of the largest database of programs, Laryngoscope Investigative Otolaryngology, 2022.

• Reframing Our Approach to Facial Analysis, Otolaryngology–Head & Neck Surgery, 2022.

• Misestimating Misattribution of Mortality to Otolaryngology Departments in US News & World Report Rankings, Otolaryngology–Head & Neck Surgery, 2022.

• Assessment of Sudden Sensorineural Hearing Loss After COVID-19 Vaccination, JAMA Otolaryngology–Head & Neck Surgery, 2022.

• Factors affecting operative autonomy and performance during otolaryngology training: A multicenter trial, Laryngoscope Investigative Otolaryngology, 2022.

• A Rare Complication of Chronic Otitis Media: Central Skull Base Osteomyelitis Managed With Combined Endoscopic Transmastoid and Transsphenoidal Debridement, Otology & Neurotology, 2022.

• Intracochlear New Fibro-Ossification and Neuronal Degeneration Following Cochlear Implant Electrode Translocation: Long-Term Histopathological Findings in Humans, Otolaryngology–Head & Neck Surgery, 2022.

• Association of Pediatric Hearing Quality and Sports Participation: A Population-Based Study, Otolaryngology–Head & Neck Surgery, 2022.

• A Subset of Intracanalicular Vestibular Schwannomas Demonstrates Minimal Growth Over a 10-Year Period, Otology & Neurotology, 2022.

• "Transcanal view" computed tomography reformat: Applications for transcanal endoscopic ear surgery, American Journal of Otolaryngology, 2021.

• Autonomy in the Operating Room: A Multicenter Study of Gender Disparities During Surgical Training, Journal of Graduate Medical Education, 2021.

• Multi-institutional Study of Otolaryngology Resident Intraoperative Experiences for Key Indicator Procedures, Otolaryngology–Head and Neck Surgery, 2021.

• Implementation of Mobile Audiometry During the COVID-19 Pandemic, Otolaryngology–Head and Neck Surgery, 2021.

• International Survey of Operative Practices for Otologists and Neurotologists During the COVID-19 Crisis, Otology & Neurotology, 2021.

• In-Office Repair of Tympanic Membrane Perforation, Otology & Neurotology, 2021.

• Posterior petrous face meningiomas presenting with Ménière's-like syndrome: a case series and review of the literature, Journal of Neurosurgery, 2021.

• International Survey of Operative Practices for Otologists and Neurotologists During the COVID-19 Crisis, Otology & Neurotology, 2021.

• Does stapedotomy improve high frequency conductive hearing?, Laryngoscope Investigative Otolaryngology, 2021.

• In Office Repair of Tympanic Membrane Perforations, Operative Techniques in Otolaryngology–Head and Neck Surgery, 2021.

• Further Research Needed to Understand Relationship Between Tubarial Glands and Eustachian Tube Dysfunction, Otolaryngology–Head and Neck Surgery, 2021.

• Histopathology of the Incudomalleolar Joint in Cases of “Indeterminate” Presbycusis, Otolaryngology–Head and Neck Surgery, 2021.

• A Quantitative Analysis of Social Media to Determine Trends in Brain Tumor Care and Treatment, Cureus, 2020.

• Rethinking the Standard Approach to Audiometric Testing, The Hearing Journal, 2020.

• Single-surgeon parotidectomy outcomes in an academic center experience during a 15-year period, Laryngoscope Investigative Otolaryngology, 2020.

• Systematic Review of Endoscopic Ear Surgery Outcomes for Pediatric Cholesteatoma [Review], Otology & Neurotology, 2020.

• Impact of COVID-19 on Presentation of Sudden Sensorineural Hearing Loss at a Single Institution, Otolaryngology–Head and Neck Surgery, 2020.

• Labyrinthine Concussion: Historic Otopathologic Antecedents of a Challenging Diagnosis, Laryngoscope Investigative Otolaryngology, 2020.

• Aerosol Dispersion During Mastoidectomy and Custom Mitigation Strategies for Otologic Surgery in the COVID-19 Era, Otolaryngology–Head and Neck Surgery, 2020.

• Telemedicine Algorithm for the Management of Dizzy Patients, Otolaryngology–Head and Neck Surgery, 2020.

• Demonstration and Mitigation of Aerosol and Particle Dispersion during Mastoidectomy Relevant to the COVID-19 Era, Otology & Neurotology, 2020.

• A Systematic Review of Nonautologous Graft Materials Used in Human Tympanoplasty, The Laryngoscope, 2020.

• Effect of Powered Air-Purifying Respirators on Speech Recognition Among Health Care Workers, Otolaryngology–Head and Neck Surgery, 2020.

• Auditory Quality-of-Life Measures in Patients With Traumatic Brain Injury and Normal Pure Tone Audiometry, Otolaryngology–Head and Neck Surgery, 2020.

• American Neurotology Society, American Otological Society, and American Academy of Otolaryngology – Head and Neck Foundation Guide to Enhance Otologic and Neurotologic Care During the COVID-19 Pandemic, Otology & Neurotology, 2020.

• Hearing Vital Signs: Mobile Audiometry in the Emergency Department for Evaluation of Sudden Hearing Loss, Otolaryngology–Head and Neck Surgery, 2020.

• Long-Term Cochlear Implantation Outcomes in Patients Following Head Injury, Laryngoscope Investigative Otolaryngology, 2020.

• Telemedicine Services Provided to Medicare Beneficiaries by Otolaryngologists Between 2010 and 2018, JAMA Otolaryngology–Head & Neck Surgery, 2020.

• Histopathological Changes to the Peripheral Vestibular System Following Meningitic Labyrinthitis, Laryngoscope Investigative Otolaryngology, 2020.

• High-Frequency Conductive Hearing Following Total Drum Replacement Tympanoplasty, Otolaryngology–Head and Neck Surgery, 2020.

• Otopathologic Analysis of Patterns of Postmeningitis Labyrinthitis Ossificans, Otolaryngology–Head and Neck Surgery, 2020.

• Tracking Operative Autonomy and Performance in Otolaryngology Training Using Smartphone Technology: A Single Institution Pilot Study, Laryngoscope Investigative Otolaryngology, 2019.

• Assessments of Otolaryngology Resident Operative Experiences Using Mobile Technology: A Pilot Study, Otolaryngology–Head and Neck Surgery, 2019.

• Patient‐reported Auditory Handicap Measures Following Mild Traumatic Brain Injury, The Laryngoscope, 2019.

• Peripheral Vestibular Organ Degeneration After Temporal Bone Fracture: A Human Otopathology Study, The Laryngoscope, 2019.

• Location of Small Intracanalicular Vestibular Schwannomas Based on Magnetic Resonance Imaging, Otolaryngology–Head and Neck Surgery, 2019.

• Light-Based Neuronal Activation: The Future of Cranial Nerve Stimulation, Otolaryngologic Clinics of North America, 2019.

• Endoscopic-Assisted Surgical Repair of Superior Canal Dehiscence Using a Keyhole Middle Fossa Craniotomy Approach, Operative Techniques in Otolaryngology-Head and Neck Surgery, 2019.

• Bilayer Graft for Incisionless In-Office Endoscopic Repair of Tympanic Membrane Perforations: A Pilot Study, OTO Open, 2019.

• Transcanal Computed Tomography Views for Transcanal Endoscopic Lateral Skull Base Surgery: Pilot Cadaveric Study, Journal of Neurological Surgery Part B: Skull Base, 2019.

• Human Otopathology of Cochlear Implant Drill-out Procedures, Otolaryngology–Head and Neck Surgery, 2019.

NIH & Other Major Federal Funding: $633,885

• Neural Mechanisms Underlying the Auditory Phenotype of Mild Traumatic Brain Injury, NIDCD, $261,695 awarded in 2023.

• Neural Mechanisms Underlying the Auditory Phenotype of Mild Traumatic Brain Injury, NIDCD, $186,095 awarded in 2022.

• Neural Mechanisms Underlying the Auditory Phenotype of Mild Traumatic Brain Injury, NIDCD, $186,095 awarded in 2021.

Khaleel Razak, Ph.D., University of California, Riverside

Research Topic: Age-related hearing loss and cortical processing

Long-Term Goal: To systematically examine the optimal combination of hearing aids and behavioral and pharmacological approaches to delay or prevent the declines in complex sound processing seen in presbycusis. 

Published Research

• Developmental Delays in Cortical Auditory Temporal Processing in a Mouse Model of Fragile X Syndrome, Journal of Neurodevelopmental Disorders, 2023.

• Baclofen-associated Neurophysiologic Target Engagement across Species in Fragile X Syndrome, Journal of Neurodevelopmental Disorders, 2022.

• Nicotine reduces age-related changes in cortical neural oscillations without affecting auditory brainstem responses, Neurobiology of Aging, 2022.

• Neural responses to pup calls and pup odors in California mouse fathers and virgin males, Behavioural Brain Research, 2022.

• A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons, Neurobiology of Disease, 2022.

• Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome, Neurobiology of Disease, 2021.

• Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice, Journal of Neurodevelopmental Disorders, 2021.

• Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusis, Hearing Research, 2020.

• Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome, Journal of Neurodevelopmental Disorders, 2020.

• Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome, Journal of Neurophysiology, 2020.

• Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome, Neurobiology of Disease, 2020.

• Mechanisms underlying auditory processing deficits in Fragile X syndrome, The FASEB Journal, 2020.

• Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice, Journal of Neurochemistry 2020.

• Magnesium-based biodegradable microelectrodes for neural recording, Materials Science and Engineering: C, 2020.

• Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome, Neurobiology of Disease, 2020.

• Minocycline Treatment Reverses Sound Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome, Frontiers in Neuroscience, 2020.

• Formation of grassy TiO2 nanotube thin film by anodisation in peroxide electrolyte for Cr(VI) removal under ultraviolet radiation, Nanotechnology, 2020.

• Fabrication and Characterization of Biodegradable Metal Based Microelectrodes for In Vivo Neural Recording, MRS Advances, 2019

• Effects of Developmental Noise Exposure on Inhibitory Cell Densities and Perineuronal Nets in A1 and AAF of Mice, Hearing Research2019

• Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory, Neurobiology of Learning and Memory, 2019.

• Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome, Neuroscience, 2019.

• Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response, Brain Research, 2019.

• Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9, Behavioural Brain Research, 2019.

NIH & Other Major Federal Funding: $1,822,806

• Using nicotine to reverse age-related auditory processing deficits, NIA, $581,628 awarded in 2023.

• Using nicotine to reverse age-related auditory processing deficits, NIA, $600,705 awarded in 2022.

• Using nicotine to reverse age-related auditory processing deficits, NIA, $640,473 awarded in 2021.

Joseph Toscano, Ph.D., Villanova University

Research Topic: Cortical EEG measure of speech sound encoding for hearing assessment

Long-Term Goal: To develop a clinical test for identifying auditory neuropathy and other types of hearing loss that can be used for both adults and children. 

Published Research

• Decoding speech sounds from neurophysiological data: Practical considerations and theoretical implications, Psychophysiology, 2023.

• Effects of experience on recognition of speech produced with a face maskons, 2022.

• Rethinking the McGurk effect as a perceptual illusion, Attention, Perception & Psychophysics, 2021.

• Effects of face masks on speech recognition in multi-talker babble noise, PLOS One, 2021.

• The time-course of speech perception revealed by temporally-sensitive neural measures, WIREs Cognitive Science, 2020

• A graph-theoretic approach to identifying acoustic cues for speech sound categorization, Psychonomic Bulletin & Review, 2020.

• Long-lasting gradient activation of referents during spoken language processing, Journal of Memory and Language, 2020.

• Age-Related Changes in Temporal and Spectral Cue Weights in Speech, Language and Speech, 2019.

• Reassessing the electrophysiological evidence for categorical perception of Mandarin lexical tone: ERP evidence from native and naïve non-native Mandarin listeners, Attention, Perception & Psychophysics, 2019.

• Electrophysiological Evidence for Top-Down Lexical Influences on Early Speech Perception, Psychological Science, 2019

NIH & Other Major Federal Research Funding: $421,456

• Integrating information across levels of processing during real-time spoken language comprehension, NSF, $421,456 awarded in 2020.

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2011 Grantees

Joseph Bochner, Ph.D., Rochester Institute of Technology

Research Topic: Auditory Experience, Critical Periods, and the Development of Categorical Perception in Cochlear Implant Users: A Preliminary Investigation

Long-Term Goal: To understand the impact of sensorineural (peripheral) hearing loss may extend to central auditory processing when the onset of hearing loss occurs at birth or within the first two to three years of life.

Published Research

• Phoneme Categorization in Prelingually Deaf Adult Cochlear Implant Users, Journal of Speech, Language, and Hearing Research, 2022.

• Effects of Sound Quality on the Accuracy of Telephone Captions Produced by Automatic Speech Recognition: A Preliminary Investigation, American Journal of Audiology, 2022.

Angela Yarnell Bonino, Ph.D., CCC-A., The University of North Carolina at Chapel Hill

Research Topic: Toddlers’ and preschoolers’ ability to hear speech in noise: Assessing performance with a two-interval, observer-based procedure


Long-Term Goal To examine toddlers’ and preschoolers’ auditory functioning with stimuli that are believed to be highly related to speech and language abilities.

Published Research

• Identifying Reduced Hearing in Children Who Have Developmental Disabilities: Insights for Inclusive Research Practices with Electronic Health Records, Frontiers in Psychology, 2023.

• Development of Masked Speech Detection Thresholds in 2- to 15-year-old Children: Speech-Shaped Noise and Two-Talker Speech Maskers, Ear & Hearing, 2021.

• Visual reinforcers designed for children with developmental disabilities, Journal of Early Hearing Detection and Intervention, 2021.

• Interrater Reliability for a Two-Interval, Observer-Based Procedure for Measuring Hearing in Young Children, American Journal of Audiology, 2020.

• Measuring open-set, word recognition in school-aged children: Corpus of monosyllabic target words and speech maskers, The Journal of the Acoustical Society of America, 2019.

• Using Visual Supports to Facilitate Audiological Testing for Children With Autism Spectrum Disorder, American Journal of Audiology, 2019.

• Behavioral Assessment of Hearing in 2- to 7-Year-Old Children: Evaluation of a Two-Interval, Observer-Based Procedure Using Conditioned Play-Based Responses, American Journal of Audiology, 2019.

NIH & Other Major Federal Research Funding: $536,398

• Measuring hearing in children with developmental differences, NIDCD, $181,343 awarded in 2022.

• Measuring Hearing in Children with Developmental Differences, NIDCD, $202,693 awarded in 2021.

• Measuring Hearing in Children with Developmental Differences, NIDCD, $152,362 awarded in 2020.

Inyong Choi, Ph.D., University of Iowa

Research Topic: Neural correlates of selective listening deficits in a multiple-speaker environment

Long-Term Goal: To develop clinical tests to identify specific hearing deficits that are currently undiagnosed and raise awareness of such “hidden” hearing loss.

Published Research

• Spectral Grouping of Electrically Encoded Sound Predicts Speech-in-Noise Performance in Cochlear Implantees, Journal of the Association for Research in Otolaryngology, 2023.

• Immediate neural impact and incomplete compensation after semantic hub disconnection, Nature Communications, 2023.

• Neural Correlates of Individual Differences in Speech-in-Noise Performance in a Large Cohort of Cochlear Implant Users, Ear & Hearing, 2023.

• Differences in Neural Encoding of Speech in Noise Between Cochlear Implant Users with and without Preserved Acoustic Hearing, Hearing Research, 2022.

• Strength of Attentional Modulation on Cortical Auditory Evoked Responses Correlates with Speech-in-Noise Performance in Bimodal Cochlear Implant Users, Trends in Hearing, 2022.

• Revealing differential importance of word categories in spoken sentence comprehension using phoneme-related representation, Journal of Integrative Neuroscience, 2022.

• Effect of Noise Reduction on Cortical Speech-in-Noise Processing and Its Variance due to Individual Noise Tolerance, Ear & Hearing, 2021.

• Validation of the Iowa Test of Consonant Perception, The Journal of the Acoustical Society of America, 2021.

• Auditory Working Memory Explains Variance in Speech Recognition in Older Listeners Under Adverse Listening Conditions, Clinical Interventions in Aging, 2020.

• A computational study to model the effect of electrode-to-auditory nerve fiber distance on spectral resolution in cochlear implant, PLOS ONE, 2020.

• Topographic specificity of alpha power during auditory spatial attention, NeuroImage, 2020.

• Semantic-hierarchical model improves classification of spoken-word evoked electrocorticography, Journal of Neuroscience Methods, 2019.

• Causal links between parietal alpha activity and spatial auditory attention, eLife, 2019.

• Impoverished auditory cues limit engagement of brain networks controlling spatial selective attention, NeuroImage, 2019.

• Non-Invasive Assays of Cochlear Synaptopathy, bioRxiv, 2019.

• Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users, Hearing Research, 2018.

NIH & Other Major Federal Research Funding: $1,888,532

• Project 2: Central Auditory Integration and Plasticity, NIDCD, $525,886 awarded in 2023.

• Identifying the Sources of Degraded Speech-in-Noise Understanding and Individualized Therapeutic Options, CDMRP, $1,362,646 awarded in 2018.

Christina Reuterskiöld, Ph.D., New York University

Research Topic: Rhyme Awareness in Children with Cochlear Implants: Investigating the Effect of a Degraded Auditory System on Auditory Processing, Language, and Literacy Development

Long-Term Goal: To better understand the implications of early auditory deprivation on auditory processing, language, and literacy learning in children, which will ultimately lead to improvements in targeted intervention and educational approaches for these children.

Published Research

• Longitudinal Social and Communication Outcomes in Children with Autism Raised in Bi/Multilingual Environments, Journal of Autism and Developmental Disorders, 2021.

• Rhyme Awareness in Children With Normal Hearing and Children With Cochlear Implants: An Exploratory Study, Frontiers in Psychology, 2019.

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Richard A. Felix II, Ph.D., Washington State University

Research Topic: Neural mechanisms underlying deficits encoding temporal sound features associated with central auditory processing disorder

Long-Term Goal: To gain a thorough understanding of the neural mechanisms that govern the temporal processing of speech. This work has the potential to impact those with hearing loss by providing vital information needed for treatments designed to ameliorate listening problems associated with CAPD.

Published Research

• Nicotinic acetylcholine receptor subunit α7 knockout mice exhibit degraded auditory temporal processing, Journal of Neurophysiology, 2019.

• Temporal information in tones, broadband noise and natural vocalizations is conveyed by differential spiking responses in the Superior Paraolivary Nucleus, European Journal of Neuroscience, 2018.

• Subcortical pathways: Towards a better understanding of auditory disorders, Hearing Research, 2018.

• Serotonin modulates response properties of neurons in the dorsal cochlear nucleus of the mouse, Hearing Research, 2017.

• A time to listen: Perinatal smoking affects the development of temporal sound processing, The Journal of Physiology, 2017.

• Octopus Cells in the Posteroventral Cochlear Nucleus Provide the Main Excitatory Input to the Superior Paraolivary Nucleus, Frontiers in Neural Circuits, 2017.

• Forward masking in the superior paraolivary nucleus of the rat, Brain Structure & Function, 2017.

• Dopaminergic projections of the subparafascicular thalamic nucleus to the auditory brainstem, Hearing Research, 2016.

Nathan Higgins, Ph.D., Vanderbilt University

Research Topic: Biomarkers of spatial processing in auditory cortex measured with functional near-infrared spectroscopy

Long-Term Goal: To establish consistent biomarkers for central auditory processing, and determine the utility of fNIRS for a variety of patient populations by quantifying the influence of task-related attention on cortical activity.

Published Research

• Head movement and its relation to hearing, Frontiers in Psychology, 2023.

• Understanding the role of head and body movement when navigating a complex auditory scene, Frontiers in Neuroscience, 2023.

• Adaptation in the sensory cortex drives bistable switching during auditory stream segregation, Neuroscience of Consciousness, 2023.

• Large group differences in binaural sensitivity are represented in pre-attentive responses from auditory cortex, Journal of Neurophysiology, 2022.

• Defining functional spatial boundaries using a spatial release from masking task, JASA Express Letters, 2022.

• Resetting of Auditory and Visual Segregation Occurs After Transient Stimuli of the Same Modality, Frontiers in Psychology, 2021.

• Neural correlates of perceptual switching while listening to bistable auditory streaming stimuli, NeuroImage, 2020.

• Sensitivity to an Illusion of Sound Location in Human Auditory Cortex, Frontiers in Systems Neuroscience, 2017.

• Evidence for cue-independent spatial representation in the human auditory cortex during active listening, Proceedings of the National Academy of Sciences, 2017.

Elizabeth McCullagh, Ph.D., University of Colorado

Research Topic: The role of the MNTB in sound localization impairments in autism spectrum disorder and CAPD

Long-Term Goal: To verify a theory that autism may be caused by an imbalance of excitatory and inhibitory synapses, particularly in sensory systems, which would lead to a decreased ability to separate competing sound sources.

Published Research

• Parasite effects on receivers in animal communication: Hidden impacts on behavior, ecology, and evolution, Proceedings of the National Academy of Sciences of the United States of America, 2024.

• Hearing ability of prairie voles (Microtus ochrogaster), Journal of the Acoustical Society of America, 2024.

• Neural Markers of Sensory Processing in Development, Frontiers in Integrative Neuroscience, 2023.

• Recent Advances in Mechanisms and Therapeutics for Fragile X Syndrome and Autism, Frontiers in Neuroscience, 2023.

• The Continued Importance of Comparative Auditory Research to Modern Scientific Discovery, Hearing Research, 2023.

• Current Best Practices for Analysis of Dendritic Spine Morphology and Number in Neurodevelopmental Disorder Research, ACS chemical neuroscience, 2023.

• Diet in treatment of autism spectrum disorders, Frontiers in Neuroscience, 2022.

• Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices, Journal of Visualized Experiments: JoVE, 2022.

• Auditory Brainstem Development of Naked Mole-Rats (Heterocephalus glaber), Proceedings. Biological Sciences, 2022.

• Alterations in the Sound Localization Pathway Related to Impaired Cocktail-Party Performance, Frontiers in Neuroscience, 2022.

• Myelination Deficits in the Auditory Brainstem of a Mouse Model of Fragile X Syndrome, Frontiers in Neuroscience, 2021.

• Mechanisms underlying auditory processing deficits in Fragile X syndrome, The FASEB Journal, 2020.

• Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model, eNeuro, 2020.

• Enhancement of de novo sequencing, assembly and annotation of the Mongolian gerbil genome with transcriptome sequencing and assembly from several different tissues, BMC Genomics, 2019.

• Low-latency single channel real-time neural spike sorting system based on template matching, PloS One2019

• Request a woman scientist: A database for diversifying the public face of science, PLoS biology, 2019.

  Metformin ameliorates core deficits in a mouse model of fragile X syndrome, Nature Medicine, 2017.

• Effects of an Extended Cage-change Interval on Ammonia Levels and Reproduction in Mongolian Gerbils (Meriones unguiculatus), Journal of the American Association for Laboratory Animal Science: JAALAS, 2017.

• An Integrated Circuit for Simultaneous Extracellular Electrophysiology Recording and Optogenetic Neural Manipulation, IEEE transactions on bio-medical engineering, 2017.

• Tonotopic alterations in inhibitory input to the medial nucleus of the trapezoid body in a mouse model of Fragile X syndrome, The Journal of Comparative Neurology, 2017.

NIH & Other Major Federal Funding: $3,724,618

• RaMP: Oklahoma Network addressing human impacts across biological processes (ON-RaMP), NSF, $2,719,700 awarded in 2022.

• Myelination Deficits Underlying Auditory Issues in Fragile X Syndrome, NICHD & NIGMS, $562,819 awarded in 2022.

• Myelination Deficits Underlying Auditory Issues in Fragile X Syndrome, NICHD & NIGMS, $442,099 awarded in 2021.

Nirmal Kumar Srinivasan, Ph.D., Towson University

Research Topic: Understanding and decoding CAPD in adults

Long-Term Goal: To better understand the difficulties encountered by listeners with CAPD in complex listening environment.

Published Research

• Factors Underlying Masking Release by Voice-Gender Differences and Spatial Separation Cues in Multi-Talker Listening Environments in Listeners with and without Hearing Loss, Frontiers in Neuroscience, 2022.

• Differential Effects of Binaural Pitch Fusion Range on the Benefits of Voice Gender Differences in a "Cocktail Party" Environment for Bimodal and Bilateral Cochlear Implant Users, Ear & Hearing, 2022.

• Effect of gap detection threshold and localisation acuity on spatial release from masking in older adults, International Journal of Audiology, 2021.

• Comparing Spatial Release From Masking Using Traditional Methods and Portable Automated Rapid Testing iPad App, American Journal of Audiology, 2020.

• Pilot Comparison of Adjustment Protocols of Personal Sound Amplification Products, Seminars in Hearing, 2019.

• The role of early and late reflections on spatial release from masking: Effects of age and hearing loss, The Journal of the Acoustical Society of America, 2017.

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Hari Bharadwaj, Ph.D., Massachusetts General Hospital

Research Topic: A systems approach to characterization of subcortical and cortical contributions to temporal processing deficits in CAPD

Long-Term Goal: To understand the physiological mechanisms that allow us to listen and communicate in noisy settings, thereby illuminating why different groups of individuals have difficulty in such settings, and to leverage this understanding to develop noninvasive objective tools that can be used in the diagnosis and stratification (“subtyping”) of a diverse yet overlapping set of communication disorders.

Published Research

• Still an Ineffective Method With Supertrials/ERPs-Comments on "Decoding Brain Representations by Multimodal Learning of Neural Activity and Visual Features", IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023.

• Both Stronger and Weaker Cerebro-Cerebellar Functional Connectivity Patterns During Processing of Spoken Sentences in Autism Spectrum Disorder, Human Brain Mapping, 2023.

• A Multi-Channel EEG Mini-Cap Can Improve Reliability for Recording Auditory Brainstem Responses in Chinchillas, Journal of Neuroscience Methods, 2023.

• Web-based Psychoacoustics: Hearing Screening, Infrastructure, and Validation, Behavior Research Methods, 2023.

• Induced Alpha and Beta Electroencephalographic Rhythms Covary with Single-Trial Speech Intelligibility in Competition, Scientific Reports, 2023.

• No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children, Journal of Autism and Developmental Disorders, 2023.

• The effects of broadband elicitor duration on a psychoacoustic measure of cochlear gain reduction, The Journal of the Acoustical Society of America, 2023.

• Atypical Cortical Processing of Bottom-up Speech Binding Cues in Children with Autism Spectrum Disorders, NeuroImage: Clinical, 2023.

• Confounds in the Data—Comments on “Decoding Brain Representations by Multimodal Learning of Neural Activity and Visual Features”, IEEE Transactions on Pattern Analysis and Machine Intelligence, 2022.

• Cross-species experiments reveal widespread cochlear neural damage in normal hearing, Communications Biology, 2022.

• Remote testing for psychological and physiological acoustics, The Journal of the Acoustical Society of America, 2022.

• Individualized Assays of Temporal Coding in the Ascending Human Auditory System, eNeuro, 2022.

• Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis, PLOS Biology, 2022.

• Effect of Noise Reduction on Cortical Speech-in-Noise Processing and Its Variance due to Individual Noise Tolerance, Ear & Hearing, 2021.

• Modulation masking and fine structure shape neural envelope coding to predict speech intelligibility across diverse listening conditions, The Journal of the Acoustical Society of America, 2021.

• Altered maturation and atypical cortical processing of spoken sentences in autism spectrum disorder, Progress in Neurobiology, 2021.

• What’s been hidden in hidden hearing loss, Neuron, 2021.

• The Perils and Pitfalls of Block Design for EEG Classification Experiments, IEEE Transactions on Pattern Analysis and Machine Intelligence, 2020.

• Comment on 'Rapid acquisition of auditory subcortical steady state responses using multichannel recordings,’ Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 2020.

• Electroencephalographic signatures of theneural representation of speech during selective attention, eNeuro, 2019.

• Non-Invasive Assays of Cochlear Synaptopathy, bioRxiv, 2019.

• Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder, Autism Research, 2016.

• Altered Onset Response Dynamics in Somatosensory Processing in Autism Spectrum Disorder, Frontiers in Neuroscience, 2016.

• Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy, The Journal of Neuroscience, 2016.

NIH & Other Major Federal Research Funding: $1,632,361

• Individualized Assays of Supra-Threshold Hearing Deficits, NIDCD, $376,521 awarded in 2020.

• Individualized Assays of Supra-Threshold Hearing Deficits, NIDCD, $376,737 awarded in 2019.

• Individualized Assays of Supra-Threshold Hearing Deficits, NIDCD, $376,948 awarded in 2018.

• Neurodatarr: Collaborative Research: Testing the Relationship between Musical Training and Enhanced Neural Coding and Perception in Noise, NSF, $125,000 awarded in 2018.

• Individualized Assays of Supra-Threshold Hearing Deficits, NIDCD, $377,155 awarded in 2017.

Andrew Dimitrijevic, Ph.D., Cincinnati Children's Hospital Medical Center

Research Topic: Sensory and Cognitive Processing in Children with Auditory Processing Disorders: Behavior and Electrophysiology

Long-Term Goal: To address whether there are subtypes of CAPD arising from deficits of bottom-up or top-down processing. Bottom-up processing refers to how the sound signal is encoded up to the level of the brain (i.e., ear to auditory nerve through the brainstem and up to the brain). Top-down processing is what the brain does with that information and includes cognition and attention. Understanding the mechanism of the CAPD will help direct clinicians as to what intervention may be most appropriate.

Published Research

• Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework, Brain Sciences, 2024.

• Neural Responses to Naturalistic Audiovisual Speech are Related to Listening Demand in Cochlear Implant Users, Frontiers in Human Neuroscience, 2022.

• Evidence of Visual Crossmodal Reorganization Positively Relates to Speech Outcomes in Cochlear Implant Users, Scientific Reports, 2022.

• Objective and Subjective Hearing Difficulties Are Associated With Lower Inhibitory Control, Ear and Hearing, 2022.

• Local magnetic delivery of recombinant adeno-associated virus AAV2(quad Y-F) mediated brain-derived neurotrophic factor gene therapy restores hearing after noise injury, Molecular Therapy, 2021.

• Cortical alpha oscillations in cochlear implant users reflect subjective listening effort during speech-in-noise perception, PLOS ONE, 2021.

• Neural correlates of visual stimulus encoding and verbal working memory differ between cochlear implant users and normal-hearing controls, European Journal of Neuroscience, 2021.

• Poor early cortical differentiation of speech predicts perceptual difficulties of severely hearing-impaired listeners in multi-talker environments, Scientific Reports, 2020.

• Data for an Advanced Microstructural and Electrochemical Datasheet on 18650 Li-ion Batteries with Nickel-Rich NMC811 Cathodes and Graphite-Silicon Anodes, Data in Brief, 2020.

• Acoustic Change Responses to Amplitude Modulation in Cochlear Implant Users: Relationships to Speech Perception, Frontiers in Neuroscience, 2020.

• Neural indices of listening effort in noisy environments, Scientific Reports, 2019.

• Cortical Alpha Oscillations Predict Speech Intelligibility, Frontiers in Human Neuroscience, 2017.

• Human Envelope Following Responses to Amplitude Modulation: Effects of Aging and Modulation Depth, Ear and Hearing, 2016.

• Characterizing Information Flux Within the Distributed Pediatric Expressive Language Network: A Core Region Mapped Through fMRI-Constrained MEG Effective Connectivity Analyses, Brain Connectivity, 2016.

• Auditory cortical activity to different voice onset times in cochlear implant users, Clinical Neuropsychology, 2016.

Beula Magimairaj, Ph.D., CCC-SLP., University of Central Arkansas

Research Topic: Moving the science forward through interdisciplinary collaborative research integrating hearing, language, and cognitive science

Long-Term Goal: To develop a sensitive and valid test that can serve as a front-end differential screening tool for children suspected to have CAPD. Such an assessment tool will be able to reliably characterize auditory processing and attention, language, and memory deficits that are known to coexist in some children diagnosed with CAPD.

Published Research

• Auditory Closure with Visual Cues: Relationship with Working Memory and Semantic Memory, JASA Express Letters, 2022.

• Online Administration of the Test of Narrative Language-Second Edition: Psychometrics and Considerations for Remote Assessment, Language, Speech and Hearing Services in Schools, 2022.

• Speech Perception in Noise Predicts Oral Narrative Comprehension in Children With Developmental Language Disorder, Frontiers in Psychology, 2021.

• Auditory processing in children: Role of working memory and lexical ability in auditory closure, PLOS ONE, 2020.
  Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties, American Journal of Audiology, 2020.

• Auditory distraction in school-age children relative to individual differences in working memory capacity, Attention, Perception, & Psychophysics, 2020.

• Access to Pediatric Audiological Evaluation Facilities for Infants and Young Children in the United States: Results from the EHDI-PALS System, The Journal of Early Hearing Detection and Intervention, 2019.

• Working Memory and Auditory Processing in School-Age Children, Language, Speech, and Hearing Services in Schools, 2018.

• Parent-rating vs performance-based working memory measures: Association with spoken language measures in school-age children, Journal of Communication Disorders, 2018.

• Children's Speech Perception in Noise: Evidence for Dissociation From Language and Working Memory, Journal of Speech, Language, and Hearing Research, 2018.

• Role of working memory and lexical knowledge in perceptual restoration of interrupted speech, The Journal of the Acoustical Society of America, 2017.

• A Survey of Undergraduate Capstone Course Objectives in Communication Sciences and Disorders: Current Trends and Future Implications, Journal of Allied Health, 2017.

• Psycholinguistic mechanisms supporting school-age children's comprehension of spoken directions: A preliminary study, Speech, Language and Hearing, 2016.

Kenneth Vaden, Medical University of South Carolina

Research Topic: Adaptive control of auditory representations in listeners with central auditory processing disorder

Long-Term Goal: To develop methods to assess the quality of speech representations based on brain activity and characterize top-down control systems that interact with the auditory cortex. The results of this study will improve the understanding of a specific top-down control mechanism and examine when and how adaptive control enhances speech recognition for people with CAPD.

Published Research

• Auditory Cortex Asymmetry Associations with Individual Differences in Language and Cognition, Brain Sciences, 2024.

• Evidence for conflict monitoring during speech recognition in noise, Psychonomic Bulletin & Review, 2023.

• Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss, PLoS Genetics, 2023.

• Metabolic and Sensory Components of Age-Related Hearing Loss: Associations With Distortion- and Reflection-Based Otoacoustic Emissions, Trends in Hearing, 2023.

• Deep learning classification of reading disability with regional brain volume features, NeuroImage, 2023.

• Metabolic and Sensory Components of Age-Related Hearing Loss, Journal of the Association for Research in Otolaryngology, 2022.

• Evidence for cortical adjustments to perceptual decision criteria during word recognition in noise, Neuroimage, 2022.

• Cortical asymmetries at different spatial hierarchies relate to phonological processing ability, PLoS Biology, 2022.

• Unique patterns of hearing loss and cognition in older adults’ neural responses to cues for speech recognition difficulty, Brain Structure and Function, 2021.

• The Topology of Pediatric Structural Asymmetries in Language-Related Cortex, Symmetry, 2020.

• Translational and Interdisciplinary Insights into Presbyacusis: A Multidimensional Disease, Hearing Research, 2020.

• Fully synthetic neuroimaging data for replication and exploration, NeuroImage, 2020.

• Age Effects on Cochlear Reflectance in Adults, Ear and Hearing, 2020.

• Age-Related Hearing Loss Associations With Changes in Brain Morphology, Trends in Hearing, 2019.

• A deformation-based approach for characterizing brain asymmetries at different spatial scales of resolution, Journal of Neuroscience Methods, 2019.

• A pericallosal lipoma case with evidence of surface dyslexia, Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 2019.

• Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse, NeuroImage: Clinical, 2019.

• Cingulo-opercular adaptive control for younger and older adults during a challenging gap detection task, Journal of Neuroscience Research, 2019.

• Age effects on perceptual organization of speech: Contributions of glimpsing, phonemic restoration, and speech segregation, The Journal of the Acoustical Society of America, 2018.

• Reading Profiles in Multi-Site Data With Missingness, Frontiers in Psychology, 2018.

• Transient-Evoked Otoacoustic Emissions Reflect Audiometric Patterns of Age-Related Hearing Loss, Trends in Hearing, 2018.

• Complementary metrics of human auditory nerve function derived from compound action potentials, Journal of Neurophysiology, 2018.

• Orthographic influence on spoken word identification: Behavioral and fMRI evidence, Neuropsychologia, 2018.

• Common Brain Structure Findings Across Children with Varied Reading Disability Profiles, Scientific Reports, 2017.

• Auditory, Visual and Audiovisual Speech Processing Streams in Superior Temporal Sulcus, Frontiers in Human Neuroscience, 2017.

• Cognitive persistence: Development and validation of a novel measure from the Wisconsin Card Sorting Test, Neuropsychologia, 2017.

• Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss, Journal of Association for Research in Otolaryngology, 2017.

• A Novel Communication Value Task Demonstrates Evidence of Response Bias in Cases with Presbyacusis, Scientific Reports, 2017.

• Cingulo-opercular activity affects incidental memory encoding for speech in noise, NeuroImage, 2017.

• Aging-Resilient Associations between the Arcuate Fasciculus and Vocabulary Knowledge: Microstructure or Morphology?, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2016.

• Is Listening in Noise Worth It? The Neurobiology of Speech Recognition in Challenging Listening Conditions, Ear and Hearing, 2016.

• A case of Bilateral Perisylvian Syndrome with reading disability, Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 2016.

• Gray Matter Features of Reading Disability: A Combined Meta-Analytic and Direct Analysis Approach(1,2,3,4), eNeuro, 2016.

• Cingulo-Opercular Function During Word Recognition in Noise for Older Adults with Hearing Loss, Experimental Aging Research, 2016.

• Task-Related Vigilance During Word Recognition in Noise for Older Adults with Hearing Loss, Experimental Aging Research, 2016.

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Samira Anderson, Au.D., Ph.D., University of Maryland

Research Topic: Neural adaptation in new hearing aid users

Long-Term Goal: To improve the hearing aid fitting process through assessment of the brain’s sound processing and to determine how this processing changes with hearing aid use over the course of six months.

Published Research

• Hearing Aid Delay Effects on Neural Phase Locking, Ear and Hearing, 2024.

• Effects of aging on cortical representations of continuous speech, Journal of Neurophysiology, 2023.

• Rate Discrimination Training May Partially Restore Temporal Processing Abilities from Age-Related Deficits, Journal of the Association for Research in Otolaryngology: JARO, 2022.

• Neural Plasticity Induced by Hearing Aid Use, Frontiers in Aging Neuroscience, 2022.

• Examining the context benefit in older adults: A combined behavioral-electrophysiologic word identification study, Neuropsychologia, 2022.

• Stimulus context affects the phonemic categorization of temporally based word contrasts in adult cochlear-implant users, The Journal of the Acoustical Society of America, 2022.

• Effects of aging and hearing loss on perceptual and electrophysiological measures of pulse-rate discrimination, The Journal of the Acoustical Society of America, 2022.

• Aging Effects on Cortical Responses to Tones and Speech in Adult Cochlear-Implant Users, Journal of the Association for Research in Otolaryngology, 2021.

• Multiple Cases of Auditory Neuropathy Illuminate the Importance of Subcortical Neural Synchrony for Speech-in-noise Recognition and the Frequency-following Response, Ear & Hearing, 2021.

• Age-Related Compensation Mechanism Revealed in the Cortical Representation of Degraded Speech, Journal of the Association for Research in Otolaryngology, 2020.

• Objective evidence of temporal processing deficits in older adults, Hearing Research, 2020.

• Long-term Follow-up of a Patient With Auditory Neuropathy and Normal Hearing Thresholds, JAMA Otolaryngology--Head & Neck Surgery, 2020.

• Letter to the Editor: Possible Sex Effects on the Processing of Temporal Cues in Word Segments in Adult Cochlear-Implant Users, Trends in Hearing, 2020.

• High gamma cortical processing of continuous speech in younger and older listeners, NeuroImage, 2020.

• Exaggerated cortical representation of speech in older listeners: mutual information analysis, Journal of Neurophysiology, 2020.

• Effect of Stimulation Rate on Speech Understanding in Older Cochlear-Implant Users, Ear and Hearing, 2020.

• Neural and Cognitive Benefits of Hearing Aid Use, The Hearing Journal, 2019

• Case studies in neuroscience: Subcortical origins of the frequency-following response, Journal of Neurophysiology, 2019.

• Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users, Trends in Hearing, 2019.

• Age Effects on Neural Representation and Perception of Silence Duration Cues in Speech, Journal of speech, language, and hearing research: JSLHR, 2019.

• Speech-in-noise representation in the aging midbrain and cortex: Effects of hearing loss, PloS One, 2019.

• Effects of Aging on Perceptual and Electrophysiological Responses to Acoustic Pulse Trains as a Function of Rate, Journal of Speech, Language, and Hearing Research: JSLHR, 2019.

• Mutual information analysis of neural representations of speech in noise in the aging midbrain, Journal of Neurophysiology, 2019.

• Effects of Age, Cognition, and Neural Encoding on the Perception of Temporal Speech Cues, Frontiers in Neuroscience, 2019.

• Neural and behavioral changes after the use of hearing aids, Clinical Neurophysiology, 2018.

• Effects of Amplification on Neural Phase Locking, Amplitude, and Latency to a Speech Syllable, Ear and Hearing, 2018.

• Restoration of sensory input may improve cognitive and neural function, Neuropsychologia, 2018.

• Over-representation of speech in older adults originates from early response in higher order auditory cortex, Acta acustica united with acustica: the journal of the European Acoustics Association (EEIG), 2018.

• Age-related differences in binaural masking level differences: behavioral and electrophysiological evidence, Journal of Neurophysiology, 2018.

• Effects of Stimulus Duration on Event-Related Potentials Recorded From Cochlear-Implant Users, Ear and Hearing, 2018.

• Age-Related Differences in the Processing of Temporal Envelope and Spectral Cues in a Speech Segment, Ear and Hearing, 2018.

• Development of Phase Locking and Frequency Representation in the Infant Frequency-Following Response, Journal of Speech, Language, and Hearing Research: JSLHR, 2017.

• Evidence of degraded representation of speech in noise, in the aging midbrain and cortex, Journal of Neurophysiology, 2016.

• Effect of informational content of noise on speech representation in the aging midbrain and cortex, Journal of Neurophysiology, 2016

• Auditory Processing in Noise: A Preschool Biomarker for Literacy, PLOS Biology, 2015

• Stability and plasticity of auditory brainstem function across the lifespan, Cerebral Cortex (New York, N.Y.: 1991), 2015.

• Effects of Aging on the Encoding of Dynamic and Static Components of Speech, Ear and Hearing, 2015.

• Electrophysiologic Assessment of Auditory Training Benefits in Older Adults, Seminars in Hearing, 2015.

• Development of subcortical speech representation in human infants, The Journal of Acoustical Society of America, 2015

• Partial maintenance of auditory-based cognitive training benefits in older adults, Neuropsychologia, 2014

NIH & Other Major Federal Research Funding: $435,702

• Age-Related Changes in Neural Encoding and Perception of Temporal Speech Cues, NIDCD, $144,964 awarded in 2018.

• Age-Related Changes in Neural Encoding and Perception of Temporal Speech Cues, NIDCD, $145,402.00 awarded in 2017.

• Age-Related Changes in Neural Encoding and Perception of Temporal Speech Cues, NIDCD, $145,336 awarded in 2016.

Srikanta Mishra, Ph.D, New Mexico State University

Research Topic: Medial Efferent Mechanisms in Auditory Processing Disorders

Long-Term Goal: To understand the role efferent mechanisms in auditory processing, learning and disability. The translational goal is to develop mechanism-based and physiological tests for assessing auditory processing.

Published Research

• Explainable machine learning reveals the relationship between hearing thresholds and speech-in-noise recognition in listeners with normal audiograms, The Journal of the Acoustical Society of America, 2023.

• Auditory Deprivation During Development Alters Efferent Neural Feedback and Perception, The Journal of Neuroscience, 2023.

• Suprathreshold Auditory Processes in Listeners with Normal Audiograms but Extended High-Frequency Hearing Loss, The Journal of the Acoustical Society of America, 2023.

• Diversity, Equity, and Inclusion Initiatives of Communication Sciences and Disorder Programs Across the United States, Perspectives of the ASHA Special Interest Groups, 2022.

• Hearing Impairment in the Extended High Frequencies in Children Despite Clinically Normal Hearing, Ear & Hearing, 2022.

• Extended High-frequency Hearing Impairment Despite a Normal Audiogram: Relation to Early Aging, Speech-in-noise Perception, Cochlear Function, and Routine Earphone Use, Ear & Hearing, 2021.

• Unilateral auditory deprivation in humans: Effects on frequency discrimination and auditory memory span in the normal ear, Hearing Research, 2021.

• Auditory Development of Frequency Discrimination at Extended High Frequencies, Ear & Hearing, 2020.

• The role of efferents in human auditory development: efferent inhibition predicts frequency discrimination in noise for children, Journal of Neurophysiology, 2020.

• The role of medial efferents in human auditory development: Efferent inhibition predicts frequency discrimination in noise for children, Journal of Neurophysiology, 2020.

• Neural Encoding of Amplitude Modulations in the Human Efferent System, Journal of the Association for Research in Otolaryngology: JARO, 2019.

• Sweep-tone evoked stimulus frequency otoacoustic emissions in humans: Development of a noise-rejection algorithm and normative features, Hearing Research, 2018.

• Efferent-induced alterations in distortion and reflection otoacoustic emissions in children, The Journal of the Acoustical Society of America, 2018.

• Comparison of time-frequency methods for analyzing stimulus frequency otoacoustic emissions, The Journal of the Acoustical Society of America, 2018.

• Maturation of middle ear transmission in children, Hearing Research, 2017.

• Influence of medial olivocochlear efferents on the sharpness of cochlear tuning estimates in children, The Journal of the Acoustical Society of America, 2016.

• Time-frequency decomposition of click evoked otoacoustic emissions in children, Hearing Research, 2016.

• Rapid auditory learning of temporal gap detection, The Journal of the Acoustical Society of America, 2016.

• Influence of medial olivocochlear efferents on the sharpness of cochlear tuning estimates in children, The Journal of the Acoustical Society of America, 2016.

• Temporal Resolution of the Normal Ear in Listeners with Unilateral Hearing Impairment, Journal of the Association for Research in Otolaryngology: JARO, 2016.

• Influence of musical training on sensitivity to temporal fine structure, International Journal of Audiology, 2015.

• Auditory Learning in Children With Cochlear Implants, Journal of Speech, Language, and Hearing Research, 2015.

• Stability of the Medial Olivocochlear Reflex as Measured by Distortion Product Otoacoustic Emissions, Journal of Speech, Language, and Hearing Research, 2015.

NIH & Other Major Federal Research Funding: $1,973,222

• Development of medial efferent mechanisms in children, NIDCD, $459,969 awarded 2023.

• Development of medial efferent mechanisms in children, NIDCD, $342,250 awarded 2022.

• Development of Medial Efferent Mechanisms in Children, NIDCD, $400,898 awarded in 2021.

• Development of Medial Efferent Mechanisms in Children, NIDCD, $308,763 awarded in 2020.

• Medial Olivocochlear Reflex in Children, NIDCD, $23,342 awarded in 2018.

• Medial Olivocochlear Reflex in Children, NIDCD, $146,000 awarded in 2017.

• Medial Olivocochlear Reflex in Children, NIDCD, $146,000 awarded in 2016.

Daniel Winkowski, Ph.D., University of Maryland

Research Topic: Noise trauma induced reorganization of the auditory cortex

Long-Term Goal: To understand tinnitus at the level of neural circuits (auditory processing). Our approach offers a rather unique opportunity to sample activity within large-scale representations and local populations of neurons and, in turn, will reveal precisely how A1 micro-circuits are affected by traumatic insult to peripheral sensory organs. Thus, I intend on using this approach to build a more comprehensive understanding of how cortical micro-circuits change as a result of noise trauma.

Published Research

• Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity, International Journal of Molecular Sciences, 2022.

• Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression, JCI Insight, 2022.

• Transient Subgranular Hyperconnectivity to L2/3 and Enhanced Pairwise Correlations During the Critical Period in the Mouse Auditory Cortex, Cerebral Cortex, 2020.

• Functional organization of mouse primary auditory cortex in adult C57BL/6 and F1 (CBAxC57) mice, Scientific Reports, 2020.

• Neuronal Avalanches in Input and Associative Layers of Auditory Cortex, Frontiers in Systems Neuroscience, 2019.

• Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment, Translational Psychiatry, 2018.

• Small Networks Encode Decision-Making in Primary Auditory Cortex, Neuron, 2018

• Orbitofrontal Cortex Neurons Respond to Sound and Activate Primary Auditory Cortex Neurons, Cerebral Cortex, 2018

• Sublaminar Subdivision of Mouse Auditory Cortex Layer 2/3 Based on Functional Translaminar Connections, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2017.

• Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder, Cell Reports, 2017.

• Particle Tracking Facilitates Real Time Capable Motion Correction in 2D or 3D Two-Photon Imaging of Neuronal Activity, Frontiers in Neural Circuits, 2017.

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Alan Kan, Ph.D., University of Wisconsin, Madison

Research Topic: Exploiting the “better ear” in bilateral cochlear implants for improved speech understanding in noisy situations and Auditory Processing.

Dr. Kan was also funded for his research in 2014.

Long-Term Goal: To close the gap in speech understanding performance between cochlear implant users and normal hearing listeners. The primary outcome of this study will help determine whether the “better ear” strategy will provide a significant benefit for cochlear implant users, and whether this strategy for listening is desirable.

Published Research

• Lateralization of Binaural Envelope Cues Measured with a Mobile Cochlear-Implant Research Processor, The Journal of the Acoustical Society of America, 2023.

• Lateralization of Interaural Time Differences with Mixed Rates of Stimulation in Bilateral Cochlear Implant Listeners, The Journal of the Acoustical Society of America, 2023.

• Asymmetric Temporal Envelope Sensitivity: Within- and Across-Ear Envelope Comparisons in Listeners with Bilateral Cochlear Implants, The Journal of the Acoustical Society of America, 2022.

• Investigating Effortful Speech Perception Using fNIRS and Pupillometry Measures, Current Research in Neurobiology, 2022.

• Pitch Perception With the Temporal Limits Encoder for Cochlear Implants, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022.

• Sound source localization patterns and bilateral cochlear implants: Age at onset of deafness effects, PLoS One, 2022.

• The Impact of Synchronized Cochlear Implant Sampling and Stimulation on Free-Field Spatial Hearing Outcomes: Comparing the ciPDA Research Processor to Clinical Processors, Ear & Hearing, 2021.

• Evaluating the Impact of Age, Acoustic Exposure, and Electrical Stimulation on Binaural Sensitivity in Adult Bilateral Cochlear Implant Patients, Brain Sciences, 2020.

• Auditory Attention and Spatial Unmasking in Children With Cochlear Implants, Trends in Hearing, 2020.

• Development of Binaural Sensitivity: Eye Gaze as a Measure of Real-time Processing, Frontiers in Systems Neuroscience, 2020.

• Auditory motion tracking ability of adults with normal hearing and with bilateral cochlear implants, The Journal of the Acoustical Society of America, 2019.

• Effect of channel separation and interaural mismatch on fusion and lateralization in normal-hearing and cochlear-implant listeners, The Journal of the Acoustical Society of America, 2019.

• Asymmetric temporal envelope encoding: Implications for within- and across-ear envelope comparison, The Journal of the Acoustical Society of America, 2019.

• Restoration of spatial hearing in adult cochlear implant users with single-sided deafness, Hearing Research, 2019.

• Temporal dynamics and uncertainty in binaural hearing revealed by anticipatory eye movements, The Journal of the Acoustical Society of America, 2019.

• Improving Speech Recognition in Bilateral Cochlear Implant Users by Listening With the Better Ear, Trends in Hearing, 2018.

• Mixed stimulation rates to improve sensitivity of interaural timing differences in bilateral cochlear implant listeners, The Journal of the Acoustical Society of America, 2018.

• The Effect of Simulated Interaural Frequency Mismatch on Speech Understanding and Spatial Release From Masking, Ear and Hearing, 2018.

• Use of Research Interfaces for Psychophysical Studies With Cochlear-Implant Users, Trends in Hearing, 2017.

• Binaural hearing with electrical stimulation, Hearing Research, 2016.

• Effects of interaural pitch-matching and auditory image centering on binaural sensitivity in cochlear-implant users, Ear and Hearing, 2015.

• Limitations on Monaural and Binaural Temporal Processing in Bilateral Cochlear Implant Listeners, Journal of the Association for Research in Otolaryngology: JARO, 2015.

• Effect of multi-electrode configuration on sensitivity to interaural timing differences in bilateral cochlear-implant users, The Journal of the Acoustical Society of America, 2015.

• Evidence for a neural source of the precedence effect in sound localization, Journal of Neurophysiology, 2015.

• Binaural hearing with electrical stimulation, Hearing Research, 2015.

• Investigating Long-Term Effects of Cochlear Implantation in Single-Sided Deafness: A Best Practice Model for Longitudinal Assessment of Spatial Hearing Abilities and Tinnitus Handicap, Otology and Neurotology, 2014.

• Spatial hearing benefits demonstrated with presentation of acoustic temporal fine structure cues in bilateral cochlear implant listeners, The Journal of the Acoustical Society of America, 2014.

• Evidence for a neural source of the precedence effect in sound localization, Journal of Neurophysiology, 2014.

• Speech Perception in Noise with a Harmonic Complex Excited Vocoder, Journal of the Association for Research in Otolaryngology, 2014.

• Effect of mismatched place-of-stimulation on binaural fusion and lateralization in bilateral cochlear-implant users, Journal of the Acoustical Society of America, 2013.

• Effect of mismatched place-of-stimulation on the salience of binaural cues in conditions that simulate bilateral cochlear-implant listening, Journal of the Acoustical Society of America, 2013.

• Mapping procedures can produce non-centered auditory images in bilateral cochlear implantees, The Journal of the Acoustical Society of America, 2013.

NIH & Other Major Federal Research Funding: $459,000

• Restoring Binaural Hearing Abilities to Bilateral Cochlear Implant Users, NIDCD, $153,000 awarded in 2018.

• Restoring Binaural Hearing Abilities to Bilateral Cochlear Implant Users, NIDCD, $153,000 awarded in 2017.

• Restoring Binaural Hearing Abilities to Bilateral Cochlear Implant Users, NIDCD, $153,000 awarded in 2016.

Ross Maddox, Ph.D., University of Washington

Research Topic: Relating behavior to brain in an audio-visual scene

Long-Term Goal: To investigate the specific behavioral effects of audio-visual binding and its processing in the brain.

Published Research

• Subcortical responses to music and speech are alike while cortical responses diverge, Scientific Reports, 2024.

• Correlations Between Quantitative EEG Parameters and Cortical Blood Flow in Patients Undergoing Extracorporeal Membrane Oxygenation With and Without Encephalopathy, Journal of Clinical Neurophysiology, 2023.

• Performance in an Audiovisual Selective Attention Task Using Speech-Like Stimuli Depends on the Talker Identities, But Not Temporal Coherence, Trends in Hearing, 2023.

• Speech-In-Noise Comprehension is Improved When Viewing a Deep-Neural-Network-Generated Talking Face, Trends in Hearing, 2022.

• Independent mechanisms of temporal and linguistic cue correspondence benefiting audiovisual speech processing, Attention, Perception & Psychophysics, 2022.

• Cerebral Blood Flow Hemispheric Asymmetry in Comatose Adults Receiving Extracorporeal Membrane Oxygenation, Frontiers in Neuroscience, 2022.

• Spatial alignment between faces and voices improves selective attention to audio-visual speech, The Journal of the Acoustical Society of America, 2021.

• Optimizing Parameters for Using the Parallel Auditory Brainstem Response to Quickly Estimate Hearing Thresholds, Ear & Hearing, 2021.

• Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech, eLife, 2021.

• Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation, Biomedical Optics Express, 2020.

• The Parallel Auditory Brainstem Response, Trends in Hearing, 2019.

• Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer, PloS One, 2019.

• Integration of Visual Information in Auditory Cortex Promotes Auditory Scene Analysis through Multisensory Binding, Neuron, 2018

• Auditory Brainstem Responses to Continuous Natural Speech in Human Listeners, eNeuro, 2018.

• Defining Auditory-Visual Objects: Behavioral Tests and Physiological Mechanisms, Trends in Neuroscience, 2015

• Auditory selective attention is enhanced by a task-irrelevant temporally coherent visual stimulus in human listeners, eLife Sciences, 2015

• Improving spatial localization in MEG inverse imaging by leveraging intersubject anatomical differences, Frontiers in Neuroscience, 2014.

• Using neuroimaging to understand the cortical mechanisms of auditory selective attention, Hearing Research, 2014

• Directing Eye Gaze Enhances Auditory Spatial Cue Discrimination, Current Biology, 2014

• Auditory Forebrain Neurons Track Temporal Features of Time-Warped Natural Stimuli, Journal of the Association for Research in Otolaryngology, 2014

NIH & Other Major Federal Funding: $3,494,971

• Rapid Acquisition of the Frequency-Specific Auditory Brainstem Response Through Parallel Stimulus Presentation, NIDCD, $385,000 awarded in 2023.

• Subcortical and Cortical Responses in Infants Evoked by Running Speech, NIDCD, $229,918 awarded in 2023.

• Subcortical and Cortical Responses in Infants Evoked by Running Speech, NIDCD, $210,390 awarded in 2022.

• Rapid Acquisition of the Frequency-Specific Auditory Brainstem Response Through Parallel Stimulus Presentation, NIDCD, $385,000 awarded in 2022.

• Rapid Acquisition of the Frequency-Specific Auditory Brainstem Response Through Parallel Stimulus Presentation, NIDCD, $385,000 awarded in 2021.

• Rapid Acquisition of the Frequency-Specific Auditory Brainstem Response Through Parallel Stimulus Presentation, NIDCD, $385,000 awarded in 2020.

• Rapid Acquisition of the Frequency-Specific Auditory Brainstem Response Through Parallel Stimulus Presentation, NIDCD, $377,440 awarded in 2019.

• Neurodatarr: Collaborative Research: Testing the Relationship between Musical Training and Enhanced Neural Coding and Perception in Noise, NSF, $125,000 awarded in 2018.

• Visual and Auditory Perceptual Factors Affecting Spatial Release from Masking, NIDCD, $244,703 awarded in 2018.

• Visual and Auditory Perceptual Factors Affecting Spatial Release from Masking, NIDCD, $249,000 awarded in 2018.

• Visual and Auditory Perceptual Factors Affecting Spatial Release from Masking, NIDCD, $135,000 awarded in 2017.

• Visual and Auditory Perceptual Factors Affecting Spatial Release from Masking, NIDCD, $249,000 awarded in 2016.

• Visual and Auditory Perceptual Factors Affecting Spatial Release from Masking, NIDCD, $134,520 awarded in 2015.

Merri J. Rosen, Ph.D., Northeast Ohio Medical University

Research Topic: Effects of developmental conductive hearing loss on communication processing
 

Long-Term Goal: Effects of developmental conductive hearing loss on communication processing: perceptual deficits and neural correlates in an animal model.

Published Research

• Early-Life Stress Affects Mongolian Gerbil Interactions with Conspecific Vocalizations in a Sex-Specific Manner, Frontiers in Behavioral Neuroscience, 2023.

• Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway, The Journal of Neuroscience, 2023.

• Universal Automated Classification of the Acoustic Startle Reflex using Machine Learning, Hearing Research, 2023.

• Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning, Scientific Reports, 2021.

• Effects of Gap Position on Perceptual Gap Detection Across Late Childhood and Adolescence, Journal of the Association for Research in Otolaryngology: JARO, 2020.

• Late maturation of backward masking in auditory cortex, Journal of Neurophysiology, 2018.

• Development of perception and perceptual learning for multi-timescale filtered speech, The Journal of the Acoustical Society of America, 2018.

• Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss, The Journal of Neuroscience, 2016.

• Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance, Frontiers in Neuroscience, 2016.

• An improved approach to separating startle data from noise, Journal of Neuroscience Methods, 2015.

• Developmental hearing loss impairs signal detection in noise: putative central mechanisms, Frontiers in Systems Neuroscience, 2014.

NIH & Other Major Federal Funding: $3,681,339

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $496,182 awarded in 2023.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $424,941 awarded in 2022.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $457,241 awarded in 2021.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $458,567 awarded in 2020.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $379,000 awarded in 2018.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $379,000 awarded in 2017.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $370,744 awarded in 2016.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $359,884 awarded in 2015.

• Auditory Processing Deficits in Early-Onset Conductive Hearing Loss, NIDCD, $355,780 awarded in 2014.

SECOND YEAR

Bradley G. Cooper, Ph.D., Texas Christian University (see 2011 Grantees)

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Yoojin Chung, Ph.D., Mass. Eye and Ear, Harvard University

Research Topic: Restoring binaural hearing with cochlear implants in early-onset deafness

Long-Term Goal: To improve treatments for children with early-onset deafness by studying how neural mechanisms for binaural processing are altered by auditory deprivation during development and whether these effects can be reversed by CI stimulation.

Published Research

• Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals, Journal of Neurophysiology, 2022.

• Chronic Bilateral Cochlear Implant Stimulation Partially Restores Neural Binaural Sensitivity in Neonatally-Deaf Rabbits, Journal of Neuroscience, 2021.

• Rate and Temporal Coding of Regular and Irregular Pulse Trains in Auditory Midbrain of Normal-Hearing and Cochlear-Implanted Rabbits, Journal of the Association for Research in Otolaryngology: JARO, 2021.

• Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness, Journal of the Association for Research in Otolaryngology: JARO, 2019.

• Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals, Journal of the Association for Research in Otolaryngology: JARO, 2018.

• Temporal Envelope Coding by Inferior Colliculus Neurons with Cochlear Implant Stimulation, Journal of the Association for Research in Otolaryngology: JARO, 2017.

• Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants in Unanesthetized Rabbits, The Journal of Neuroscience, 2016

• Modeling Binaural Responses in the Auditory Brainstem to Electric Stimulation of the Auditory Nerve, Journal of the Association for Research in Otolaryngology, 2015

• Coding of Electric Pulse Trains Presented through Cochlear Implants in the Auditory Midbrain of Awake Rabbit: Comparison with Anesthetized Preparations, The Journal of Neuroscience, 2014

• Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants, Journal of the Association for Research in Otolaryngology, 2013.

• Better temporal neural coding with cochlear implants in awake animals, Advances in Experimental Medicine and Biology, 2013

Elizabeth Dinces, M.D., M.S., Albert Einstein College of Medicine

Research Topic: Effects of aging on selective attention in complex, multisource sound environments

Long-Term Goal: To explain mechanisms of auditory scene analysis that break down in aging.

Published Research

• Attentional Resources Are Needed for Auditory Stream Segregation in Aging, Frontiers in Aging Neuroscience, 2017.

• Intratemporal Intraneural Perineurioma of the Facial Nerve, Otology & Neurotology, 2016.

• Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos, Journal of Clinical Sleep Medicine, 2016 .

• Risk Factors for Hearing Impairment among Adults with Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), Journal of Clinical & Translational Endocrinology, 2016.

• Hearing Impairment Prevalence and Associated Risk Factors in the Hispanic Community Health Study/Study of Latinos, JAMA Otolaryngology--Head & Neck Surgery, 2015.

Kirill Vadimovich Nourski, M.D., Ph.D., University of Iowa

Research Topic: Temporal Processing in the Human Auditory Cortex

Long-Term Goal: To better understand how the different areas that comprise the auditory cortex in humans are organized and what specific roles they play in processing information about sounds, particularly, as it relates to perception of speech. Ultimately, this knowledge will contribute to finding new and/or improved solutions for people with hearing loss and auditory processing disorders.

Published Research

• Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology, PLoS Biology, 2023.

• Sensory processing of native and non-native phonotactic patterns in the alpha and beta frequency bands, Neuropsychologia, 2023.

• Surgical Outcomes and Risk Factors for Recurrence of Myxopapillary Ependymoma: A Single-Center Experience, Journal of Neurosurgery. Spine, 2023.

• Analogous Cortical Reorganization Accompanies Entry into States of Reduced Consciousness During Anesthesia and Sleep, Cerebral Cortex, 2023.

• High-Dimensional Multivariate Autoregressive Model Estimation of Human Electrophysiological Data Using fMRI Priors, NeuroImage, 2023.

• Spinal Nerve Sheath Tumors: Factors Associated with Postoperative Residual and Recurrent Tumors: A Single-Center Experience, World Neurosurgery, 2022.

• Gamma activation and alpha suppression within human auditory cortex during a speech classification task, The Journal of Neuroscience, 2022.

• Spinal Meningioma in Adults: Imaging Characteristics, Surgical Outcomes, and Risk Factors for Recurrence, World Neurosurgery, 2022.

• Multivariate autoregressive model estimation for high-dimensional intracranial electrophysiological data, Neuroimage, 2022.

• Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation, Scientific Reports, 2021.

• Arousal State-Dependence of Interactions Between Short- and Long-Term Auditory Novelty Responses in Human Subjects, Frontiers in Human Neuroscience, 2021.

• Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study, Cerebral Cortex, 2021.

• Cortical responses to auditory novelty across task conditions: An intracranial electrophysiology study, Hearing Research, 2020.

• Vertebral hemangiomas: Diagnosis and management. A single center experience, Clinical Neurology and Neurosurgery, 2020.

• Impact of the Inclusion of C2 in Posterior Cervical Fusions for Cervical Myelopathy on Sagittal Cervical Alignment, Clinical Spine Surgery, 2020.

• Cortical functional connectivity indexes arousal state during sleep and anesthesia, NeuroImage, 2020.

• Risk factors associated with reoperation in posterior cervical fusions: A large-scale retrospective analysis, Clinical Neurology and Neurosurgery, 2020.

• Indications and Outcomes for Contemporaneous Anteroposterior Surgery in Cervical Stenosis and Myelopathy: Single Center Experience, World Neurosurgery, 2020.

• Intraoperative Shoulder Traction as Cause of C5 Palsy: Magnetic Resonance Imaging Study, World Neurosurgery, 2020.

• Direct electrophysiological mapping of human pitch-related processing in auditory cortex, NeuroImage, 2019.

• Anterior and Posterior Approaches for Cervical Myelopathy: Clinical and Radiographic Outcomes, Spine, 2019.

• A Sound-Sensitive Source of Alpha Oscillations in Human Non-Primary Auditory Cortex, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2019.

• Differential responses to spectrally degraded speech within human auditory cortex: An intracranial electrophysiology study, Hearing Research, 2019.

• Predictability of vascular conflict by MRI in trigeminal neuralgia, Clinical Neurology and Neurosurgery, 2019.

• Neural Signatures of Auditory Perceptual Bistability Revealed by Large-Scale Human Intracranial Recordings, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2019.

• Management of iatrogenic spinal cerebrospinal fluid leaks: A cohort of 124 patients, Clinical Neurology and Neurosurgery, 2018.

• C5 palsy following posterior decompression and instrumentation in cervical stenosis: Single center experience and review, Clinical Neurology and Neurosurgery, 2018.

• Processing of auditory novelty across the cortical hierarchy: An intracranial electrophysiology study, NeuroImage, 2018.

• Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2018.

• Neural phase locking predicts BOLD response in human auditory cortex, NeuroImage, 2018.

• Role of the temporal pole in temporal lobe epilepsy seizure networks: an intracranial electrode investigation, Journal of Neurosurgery, 2018.

• Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report, Journal of Neurosurgery, 2018.

• Intracranial Electrophysiology of Auditory Selective Attention Associated with Speech Classification Tasks, Frontiers in Human Neuroscience, 2017

• Auditory processing in the human cortex: An intracranial electrophysiology perspective, Laryngoscope Investigative Otolaryngology, 2017.

• Electrocorticographic delineation of human auditory cortical fields based on effects of propofol anesthesia, NeuroImage, 2017.

• Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex, PLoS Biology, 2017.

• Electrocorticographic Activation within Human Auditory Cortex during Dialog-Based Language and Cognitive Testing, Frontiers in Human Neuroscience, 2016.

• Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2016.

• Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study, Journal of Neurophysiology, 2016.

• Can you hear me yet? An intracranial investigation of speech and non-speech audiovisual interactions in human cortex, Language, Cognition and Neuroscience, 2016

• Investigating the Anterior Temporal Lobe with Direct Intracranial Recordings, Neurosurgery, 2015

• Direct Physiologic Evidence of a Heteromodal Convergence Region for Proper Naming in Human Left Anterior Temporal Lobe, Journal of Neuroscience, 2015

• Modulation of response patterns in human auditory cortex during a target detection task: an intracranial electrophysiology study, International Journal of Psychophysiology, 2015

• Invasive recordings in the human auditory cortex, Handbook of Clinical Neurology, 2015.

• Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition, Current Biology: CB, 2015.

• Sound identification in human auditory cortex: Differential contribution of local field potentials and high gamma power as revealed by direct intracranial recordings, Brain and Language, 2015.

• Spectral Organization of the Human Lateral Superior Temporal Gyrus Revealed by Intracranial Recordings, Cereb Cortex, 2014

• Functional organization of human auditory cortex: Investigation of response latencies through direct recordings NeuroImage, 2014

• Mapping the temporal pole with a specialized electrode array: technique and preliminary results, Physiological Measurement, 2014

• Using speech and electrocorticography to map human auditory cortex, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014.

• Differential activation of human core, non-core and auditory-related cortex during speech categorization tasks as revealed by intracranial recordings Frontiers in Neuroscience, 2013

• Coding of repetitive transients by auditory cortex on posterolateral superior temporal gyrus in humans: an intracranial electrophysiology study, Journal of Neurophysiology, 2013

• Direct Recordings from the Auditory Cortex in a Cochlear Implant User, Journal of Associated Research in Otolaryngology, 2013

• Representation of speech in human auditory cortex: Is it special? Hearing Research, 2013
  

NIH & Other Major Federal Research Funding: $2,924,474

• Mechanisms of Loss, Recovery and Disorders of Consciousness, NIGMS, $622,604 awarded in 2023.

• Mechanisms of Anesthetic-Induced Unconsciousness, NIGMS, $602,744 awarded in 2021.

• Mechanisms of Anesthetic-Induced Unconsciousness, NIGMS, $18,665 awarded in 2020.

• Mechanisms of Anesthetic-Induced Unconsciousness, NIGMS, $490,892 awarded in 2020.

• Mechanisms of Anesthetic-Induced Unconsciousness, NIGMS $495,482.00, $495,482, awarded in 2019.

• Mechanisms of Anesthetic-Induced Unconsciousness, NIGMS, $518,143 awarded in 2018.

• CRCNS: Collaborative Research: Dynamic Models of Human Auditory Perceptual Switching Informed by Large-Scale Ecog Recordings, NSF, $175,944 awarded in 2015.

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Edward L. Bartlett, Ph.D., Purdue University

Research Topic: Cellular bases of temporal auditory processing

Long-Term Goal: To predict and redevelop the cellular dynamics that underlie in vivo responses of auditory thalamic and auditory cortical neurons in normal and pathological conditions, including age-related decline, dyslexia, and aberrant auditory experience during development.

Published Research

• Suppressing Fear in the Presence of a Safety Cue Requires Infralimbic Cortical Signaling to Central Amygdala, Neuropsychopharmacology, 2023.

• Comparison of Age-Related Declines in Behavioral Auditory Responses versus Electrophysiological Measures of Amplitude Modulation, Neurobiology of Aging, 2022.

• Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus, The Journal of Physiology, 2021.

• In vivo whole-cell recordings of stimulus-specific adaptation in the inferior colliculus, Hearing Research, 2020.

• Post-stimulatory activity in primate auditory cortex evoked by sensory stimulation during passive listening, Scientific Reports, 2020.

• Aging alters envelope representations of speech-like sounds in the inferior colliculus, Neurobiology of Aging, 2019.

• Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation, Neuroscience, 2019.

• Top-down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons, The Journal of Physiology, 2019.

• Masking Differentially Affects Envelope-following Responses in Young and Aged Animals, Neuroscience, 2018.

• Community-Building Framework for Collaborative Research Coordination across the Education and Biology Research Disciplines, CEB Life Sciences Education, 2018.

• Aging affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons, Journal of Neuroscience, 2017.

• Differences in postinjury auditory system pathophysiology after mild blast and nonblast acute acoustic trauma, Journal of Neurophysiology, 2017.

• Age-related changes in envelope-following responses at equalized peripheral or central activation, Neurobiology of Aging, 2017.

• Hierarchical winner-take-all particle swarm optimization social network for neural model fitting, Journal of Computational Neuroscience, 2017.

• Label-Free Vibrational Spectroscopic Imaging of Neuronal Membrane Potential, The Journal of Physical Chemistry Letters, 2017.

• Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss, Ear and Hearing, 2017.

• Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses, European Journal of Neuroscience, 2016.

• Age-related shifts in distortion product otoacoustic emissions peak-ratios and amplitude modulation spectra, Hearing Research, 2016.

• Postnatal development of auditory central evoked responses and thalamic cellular properties, Developmental Biology, 2014

• Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus, Journal of Neurophysiology, 2013

• The organization and physiology of the auditory thalamus and its role in processing acoustic features important for speech perception, Brain and Language, 2013.

• A Computational Model of Inferior Colliculus Responses to Amplitude Modulated Sounds in Young and Aged Rats, Frontiers in Neural Circuits, 2012

• Two-channel recording of auditory-evoked potentials to detect age-related deficits in temporal processing, Hearing Research, 2012.

• A computational model of cellular mechanisms of temporal coding in the medial geniculate body, PLOS One, 2011

NIH & Other Major Federal Research Funding: $2,050,935

• Interdisciplinary Training in Auditory Neuroscience, NIDCD, $153,329 awarded in 2023.

• Rapid Triage of Auditory Peripheral and Central Phenotypes Using a Brief but Rich Diagnostic Battery, CDMRP, $332,367 awarded in 2020.

• Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $379,509 awarded in 2016.

• Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $365,550 awarded in 2015.

• Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $370,804 awarded in 2014.

• Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $317,026 awarded in 2013.

• Measurement and Modelling of Central Auditory Processing in Aged Animals, NIDCD, $285,679 awarded in 2012.

Brenton G. Cooper, Ph.D., Texas Christian University

Research Topic: Lateralization of acoustic perception in Bengalese finches

Long-Term Goal: To develop an animal model for testing and refining treatments for hearing loss and lateralized frequency processing deficits in humans, including CAPD.

Published Research

• Preparing to Sing: Respiratory Patterns Underlying Motor Readiness for Song, Journal of Neurophysiology, 2022.

• Intraventricular Murine Aβ Infusion Elicits Hippocampal Inflammation and Disrupts the Consolidation, but not Retrieval, of Conditioned Fear in C57BL6/J Mice, Behavioural Brain Research, 2020.

• Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior, eLife, 2019.

• Differential patterns of constant frequency 50 and 22 khz usv production are related to intensity of negative affective state, Behavioral Neuroscience, 2017.

• HVC contributes toward conspecific contact call responding in male Bengalese finches, Neuroreport, 2016.

• Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure, Behavioural Brain Research, 2013.

• Laryngeal aging and acoustic changes in male rat ultrasonic vocalizations, Developmental Psychology, 2013.

• Exploring vocal recovery after cranial nerve injury, Neuroscience Letters, 2013.

• Syringeal specialization of frequency control during song production in the Bengalese finch (Lonchura striata domestica), PloS One, 2012.

• Age-related changes in the Bengalese finch song motor program, Neurobiology of Aging, 2012.

NIH & Other Major Federal Research Funding: $3,088,757

• Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $642,204 awarded in 2022.

• Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $667,697 awarded in 2021.

• Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $578,247 awarded in 2020.

• Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $573,872 awarded in 2019.

• Neural Sequences for Planning and Production of Learned Vocalizations, NINDS, $626,737 awarded in 2018.

Zhengqing Hu, M.D., Ph.D., Wayne State University School of Medicine

Research Topic: Innervation of in vitro-produced hair cell by neural progenitor-derived glutamatergic neurons
 

Long-Term Goal: To develop effective strategies to regenerate auditory pathways using stem cell-based approaches to restore hearing. If successful, the research will then explore whether stem cell-derived cells can be used to regenerate auditory cells damaged in CAPD.

Published Research

• Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model, Frontiers in Cellular Neuroscience, 2022.

• Generation of a Spiral Ganglion Neuron Degeneration Mouse Model, Frontiers in Cell and Developmental Biology, 2021.

• Insights into the molecular mechanisms regulating mammalian hair cell regeneration, Current Opinion in Otolaryngology & Head and Neck Surgery, 2021.

• Generation of Cochlear Hair Cells from Sox2 Positive Supporting Cells via DNA Demethylation, International Journal of Molecular Sciences, 2020.

• Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model, Scientific Reports, 2019.

• Identification of Neural Stem Cells from Postnatal Mouse Auditory Cortex In Vitro, Stem Cells and Development, 2019.

• Aligned contiguous microfiber platform enhances neural differentiation of embryonic stem cells, Scientific Reports, 2018.

• Embryonic Stem Cell-Derived Peripheral Auditory Neurons Form Neural Connections with Mouse Central Auditory Neurons In Vitro via the α2δ1 Receptor, Stem Cell Reports, 2018.

• Expression of Oligodendrocyte Marker during Peripheral-Central Transitional Zone Formation of the Postnatal Mouse Cochlear Nerve, Otolaryngology–Head and Neck Surgery, 2017

• Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy, Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2017.

• Stimulation of synapse formation between stem cell-derived neurons and native brainstem auditory neurons, Scientific Reports, 2017

• Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons, Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2017.

• Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells, Frontiers in Cellular Neuroscience, 2016.

• Genome-wide demethylation by 5-aza-2'-deoxycytidine alters the cell fate of stem/progenitor cells, Stem Cell Reviews and Reports, 2015.

• The astroglial reaction along the mouse cochlear nerve following inner ear damage, Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

• Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells, Cellular Reprogramming, 2014.

• The potential of stem cells for the restoration of auditory function in humans, Future Medicine, 2013.

• Sensory Epithelial Cells Acquire Features of Prosensory Cells Via Epithelial to Mesenchymal Transition, Stem Cells and Development, 2012.

• Concentration-dependent effect of NGF on cell fate determination of neural progenitor, Stem Cells and Development, 2011.

NIH & Other Major Federal Research Funding: $3,008,170

• Developing Novel Stem Cell-Based Epigenetic Approaches to Treat Hearing Loss, VA, $1,100,000 awarded in 2018–2023.

• Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2018.

• Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2017.

• Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2016.

• Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $319,770 awarded in 2015.

• Regeneration of Auditory Synaptic Contacts Using Stem Cell Based Approaches, NIDCD, $323,000 awarded in 2014.

• Reconstruction of the Ascending Neural Circuit from the Spiral Ganglion, NIDCD, $144,400 awarded in 2013.

• Reconstruction of the Ascending Neural Circuit from the Spiral Ganglion, NIDCD, $152,000 awarded in 2012.

Erin K. Purcell, Ph.D., University of Michigan

Research Topic: A stem cell-seeded nanofibrous scaffold for auditory nerve regeneration

Long-Term Goal: To regenerate auditory nerves and understand the conditions that promote neural connections with the auditory brainstem, in order to ultimately restore hearing for patients with neural hearing loss and find for therapies for individuals with CAPD.

Published Research

• Structural and Functional Changes of Deep Layer Pyramidal Neurons Surrounding Microelectrode Arrays Implanted in Rat Motor Cortex, Acta Biomaterialia, 2023.

• In Vitro Biofouling Performance of Boron-Doped Diamond Microelectrodes for Serotonin Detection Using Fast-Scan Cyclic Voltammetry, Biosensors, 2023.

• Spatiotemporal expression of RNA-seq identified proteins at the electrode interface, Acta Biomaterialia, 2023.

• Atomic Force Microscope Characterization of the Bending Stiffness and Surface Topography of Silicon and Polymeric Electrodes, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2022.

• Differential Co-Expression Analysis of RNA-Seq Data Reveals Novel Potential Biomarkers of Device-Tissue Interaction, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2022.

• Spatial Transcriptomics as a Novel Approach to Redefine Electrical Stimulation Safety, Frontiers in Neuroscience, 2022.

• Spatiotemporal patterns of gene expression around implanted silicon electrode arrays, Journal of Neuroengineering, 2020.

• Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities, Micromachines, 2021.

• Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system, Journal of Neuroengineering, 2020.

• Flexible, diamond-based microelectrodes fabricated using the diamond growth side for neural sensing, Microsystems & Nanoengineering, 2020.

• Differentiation and characterization of neurons derived from rat iPSCs, Journal of Neuroscience Methods, 2020.

• Pipette-integrated microelectrodes, Nature Biomedical Engineering, 2019.

• Neuroethical considerations of high-density electrode arrays, Nature Biomedical Engineering, 2019.

• Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface, Journal of Neural Engineering, 2018.

• Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications, Micromachines, 2018.

• Publisher Correction: Glial responses to implanted electrodes in the brain, Nature Biomedical Engineering, 2018.

• Ultracompact Microwatt CMOS Current Readout With Picoampere Noise and Kilohertz Bandwidth for Biosensor Arrays, IEEE transactions on biomedical circuits and systems, 2018.

• Glial responses to implanted electrodes in the brain, Nature Biomedical Engineering, 2017.

• Neuronal excitability and network formation on optically transparent electrode materials, International IEEE/EMBS Conference on Neural Engineering: [proceedings]. International IEEE EMBS Conference on Neural Engineering, 2017.

• Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses, Journal of Neurophysiology, 2017.

• Regenerative Electrode Interfaces for Neural Prostheses, Tissue Engineering. Part B, Reviews, 2016.

• BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells, Stem Cell Research, 2013.

• Combining topographical and genetic cues to promote neuronal fate specification in embryonic stem cells, Biomacromolecules, 2012.

NIH & Other Major Federal Research Funding: $3,185,243

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $347,024 awarded in 2023.

• Spatial transcriptomics at the interface of implanted electrodes in the brain, NINDS, $156,248 awarded in 2022.

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $347,024 awarded in 2022.

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $372,599 awarded in 2021.

• Genetic approaches to establish design rules for implantable neurotechnology, NSF, $543,269 awarded in 2020.

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $372,599 awarded in 2020.

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $77,015 awarded in 2019.

• Structural and Functional Plasticity Surrounding Implanted Neuroprostheses, NINDS, $402,997 awarded in 2019.

• Plasticity in the Electrical Properties of Neurons Surrounding Neuroprostheses, NINDS, $187,067 awarded in 2017.

• Plasticity in the Electrical Properties of Neurons Surrounding Neuroprostheses, NINDS, $225,901 awarded in 2016.

• Optical Control of Network Formation in Stem Cell-Derived Neurons, NINDS, $76,750 awarded in 2016.

• Optical Control of Network Formation in Stem Cell-Derived Neurons, NINDS, $76,750 awarded in 2015.

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