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A Cure Is Possible in Our Lifetime
 
 
A Cure Is Possible in Our Lifetime

The HRP consortium of scientists has developed a strategic research plan to develop a cure for hearing loss and tinnitus. This three-phase plan starts with discovery research and culminates in clinical trials.
 
The plan, developed specifically by the HRP scientists and updated to incorporate new findings and approaches, is a living document meant to guide but not limit the work. Relevance to this strategic plan is one of the criteria for a project to receive HRP funding.
Our Strategic Research Plan
Phase I – Discovery Research
Phase I will examine of which genes trigger the regeneration of hair cells in certain animals, as well as which genes in mammals prevent natural hair-cell regeneration or genes for regeneration therapies.. 
 
Phase II – Pathway Validation
Phase II utilizes genes identified in Phase I to trigger and explore pathways for hair cell regeneration in humans.
 
Phase III – Develop Therapies and Treatment Options
In Phase III, the HRP Consortium will partner with a pharmaceutical or other company to develop drugs that mimic the identified genes, resulting in a regenerative therapy.
 
 
How Will the HRP Analyze All This Genetic Data? 
 
In Phase I, HRP scientists will examine what genes or series of genes trigger regeneration in certain species and prevent it in others. But how will they compare the results? The answer is bioinformatics, sophisticated computation tools that have only been developed in the past few decades. 
 
Bioinformatics provides a way to analyze and compare large data sets (there may be tens of thousands of potential genes that are identified) and will allow HRP scientists to mine this data to identify the right patterns and pathways for testing in Phase II.
 
 
 
 
 
 
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