These details gleaned from this regenerative process in the mouse organoid provides insights into how mammalian supporting cells could be reprogrammed into hair cells.
Understanding Hearing Loss From Noise Damage Through Gene Expression Changes
Findings suggest several FDA-approved drugs, such as a common diabetes medication and anesthetics, could protect from noise-induced hearing loss.
Webinar Recap: The Present and Future of Inner Ear Hair Cell Regeneration
On July 12, Hearing Health Foundation (HHF) hosted “The Present and Future of Inner Ear Hair Cell Regeneration” on Zoom. This webinar was co-presented by 2009-2010 ERG scientist Ronna Hertzano, M.D., Ph.D. of the Hearing Restoration Project, and the consortium’s scientific director, Lisa Goodrich, Ph.D.
Register for Hearing Health Hour Webinar: The Present and Future of Inner Ear Hair Cell Regeneration
Goodrich and Hertzano will provide a broad overview of the techniques and tools central to the effort—including those developed by HRP scientists—and some of the challenges facing researchers in this endeavor.
Research Calls Attention to Dangerous Noise Levels in Gym
. A new University of Maryland School of Medicine (UMSOM) study found that those who attend indoor cycling (spinning) classes do not lower the intensity of their workouts when the volume is reduced to a safer decibel level. The findings were published in the January–March 2021 issue of the journal Noise & Health.
UM School of Medicine Researchers Identify Role of Crucial Protein in Development of New Hair Cells Needed for Hearing
Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. These hair cells are vital for hearing. Some of these cells amplify sounds that come into the ear, and others transform sound waves into electrical signals that travel to the brain.
Hearing Restoration Project Plans Announced for 2020–21
Hearing loss occurs when sensory hair cells of the inner ear (cochlea) are damaged or die. The goal of the Hearing Restoration Project (HRP) is to develop therapeutic methods to convert the cells that remain after damage into new, completely functional sensory hair cells, restoring hearing. We know that in most species—but not mammals, like humans and mice—hair cells robustly regenerate on their own after damage to the auditory system.
Study Charts Developmental Map of Inner Ear Sound Sensor in Mice
Scientists at the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, and their collaborators analyzed data from 30,000 cells from mouse cochlea, the snail-shaped structure of the inner ear. The results provide insights into the genetic programs that drive the formation of cells important for detecting sounds. The study also sheds light specifically on the underlying cause of hearing loss linked to Ehlers-Danlos syndrome and Loeys-Dietz syndrome.
Data Made Visual
Over the past several years, Hearing Health Foundation (HHF)’s Hearing Restoration Project (HRP) has generated a significant amount of data. Part of the challenge for HRP consortium members, as for many life scientists, comes not only from the amount of data they need to analyze but also the need to examine multi-omic datasets.
HHF Connects with Researchers at the World’s Largest Conference on Hearing & Balance Science
Nearly 1,800 hearing and balance researchers and related experts gathered Jan. 25–29, 2020, in San Jose, CA for the 43rd annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO), the largest academic association in the field. This included a number of Hearing Health Foundation (HHF)-affiliated researchers, members of the HHF Board of Directors and scientific advisory bodies, and HHF staff.