The findings suggest that blast injuries cause excessive activation of PARP1, which disrupts the brain’s natural ability to manage stress and inflammation. This reduces the activity of sirtuins, which help regulate cell repair and stress responses.

After the marriage he confided to my mom that he had developed a mild to moderate sound intolerance from frequent loud exposures in his construction job, from bulldozers, claw hammers, jackhammers, etc.

George Arthur Gates, M.D., the inaugural medical director of Hearing Health Foundation’s Hearing Restoration Project (HRP), passed away on February 8, 2025.

In audiology, we describe listening environments using the signal-to-noise ratio (SNR). The signal is what you want to hear—like your conversation partner—and noise is everything you don’t want to hear.