Manohar received his doctorate in stress physiology from Madras University, India, and is a postdoctoral fellow at SUNY Buffalo in the Center for Hearing and Deafness. Manohar’s 2017 Emerging Research Grant is funded by Hyperacusis Research Ltd.
The goal of my research at the University at Buffalo’s Center for Hearing and Deafness is to find a cure for hyperacusis, a condition that causes a reduced tolerance to everyday sound levels. Patients with hyperacusis have a low threshold for pain, which may be explained by a heightened central pain mechanism.
My research team is studying the gene and protein expression of various brain regions involved in processing auditory information and producing pain. Using a rat model, we are assessing noise-induced pain levels by using novel behavioral tests. We then analyze the gene and protein expression in the rats’ brains and correlate certain genes or proteins (biomarkers) to noise-induced pain. Identification of these biomarkers is a first step for developing treatment and earlier diagnosis of hyperacusis.
One new behavioral test I developed for the rats is the active sound avoidance paradigm. It is based on two known, innate rat behaviors: They avoid a place if it is too noisy or too bright. To do the test, we measure the time the rat spends in a dark box during a variety of amplified sounds. If it spends less time in the dark box with a moderate sound (not usually too loud for a typical rat), then it may have a noise-induced aversion to moderate sound—a symptom of hyperacusis.
Small molecular reactions that can influence our mood and behaviors have always fascinated me. I studied biochemistry as an undergraduate as well as a postgraduate, and during my pre-doctoral program, I was trained in neurochemistry. My education and work have taught me to
solve problems using a multidisciplinary approach.
Oddly, my interest in biochemistry came from my mother’s cooking, in a small village in India. She used a lot of spices in her food preparation, and as a child I always wondered how each spice influenced my taste and perception in general. I asked my mom all about the spices and why she chose to add them to our food. My curiosity for small molecules affecting perception has not faded since. I still value cooking and family. My favorite things to do outside of work are to cook and to play with my kids.
Both knowledge and practice in the lab is, I believe, the source for new inventions and hearing therapies. I feel the most rewarded when my results are confirmed or reproduced by other researchers. In the future, I hope to oversee my own auditory research lab and continue to make new findings to ultimately help those with hyperacusis.
Senthilvelan Manohar, Ph.D.’s grant is funded by Hyperacusis Research Ltd. We thank Hyperacusis Research for its support of studies that will increase our understanding of the mechanisms, causes, diagnosis, and treatments of hyperacusis and severe forms of loudness intolerance.
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Rachael R. Baiduc, Ph.D., MPH
Timothy Balmer, Ph.D.
Renee Banakis Hartl, M.D., Au.D.
Joseph H. Bochner, Ph.D.
Angela Yarnell Bonino, Ph.D., CCC-A
Inyong Choi, Ph.D.
Oscar Diaz-Horta, Ph.D.
Alisha Lambeth Jones, Au.D., Ph.D.
David Jung, M.D., Ph.D.
Ngoc-Nhi Luu, M.D., Dr. Med.
Senthilvelan Manohar, Ph.D.
Tenzin Ngodup, Ph.D.
Clive Morgan, Ph.D.
Khaleel Razak, Ph.D.
Christina Reuterskiöld, Ph.D.
Jennifer Resnik, Ph.D.
Michael Roberts, Ph.D.
Sandeep Sheth, Ph.D.
Ian Swinburne, Ph.D.
Xiaodong Tan, Ph.D.
Joseph Toscano, Ph.D.
Babak Vazifehkhahghaffari, Ph.D.
A. Catalina Vélez-Ortega, Ph.D.
Philippe Vincent, Ph.D.