This group has developed a multi-modal, cross-species analysis platform that will allow the HRP to test the role of molecules identified in our previous and ongoing experiments. Coupling gene knockout in zebrafish using the newly emerging CRISPR technology, which allows rapid testing, with pathway manipulation and gene knockouts in chicks and mice, we will be able to rapidly interrogate the many molecules the group wishes to examine. This project exemplifies the consortium’s shift towards phase II of the project.