Hearing Health Foundation

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Integrative Analysis

This group is leading the HRP’s data curation and analysis. A dedicated full-time HRP analyst is working across groups to help collect and process data, thereby facilitating a broader analysis of cell states and trajectories across species. The group is starting by annotating hair cell types from all species so that anyone in the field can assess what kind of hair cell their regeneration approaches may produce, while also easing identification of common hair cell genes, which will help the Cross-Species Epigenetics group. Analysis of the hair cells produced in mouse organoids will be performed as an example. The Ament lab is leveraging their expertise in bioinformatics, while the Hertzano lab is continuing to oversee upkeep of gEAR, with a goal of making it even easier for HRP members to post their new data and for others in the community to analyze those data. The Edge lab is leading the development of organoids as a screening platform for the future. The Heller, Hertzano, Raible, and Stone labs are validating markers by in situ hybridization across species, and all working group members will help direct the analysis.