Single Cell Transcriptional Profiling of Chicken Utricle and Basilar Papilla Sensory Epithelium Cells After Aminoglycoside-Induced Hair Cell Loss
While the HRP has excellent datasets showing the response of chicken auditory and vestibular cells to damage, the experiments examine all cells (including both hair cells and supporting cells) and are not temporally precise. In these experiments, the investigators will damage hair cells, then examine the molecular responses of hundreds of individual cells. Bioinformatics techniques will allow them to order those cells along a timeline that will reveal the molecular changes that unfold during hair cell regeneration.